PRSS8 Protein (His tag)
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- 抗原 See all PRSS8 蛋白
- PRSS8 (Protease, serine, 8 (PRSS8))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This PRSS8 protein is labelled with His tag.
- 原理
- Recombinant Human Prostasin/PRSS8 Protein (His Tag)(Active)
- 序列
- Ala 30-Arg 322
- 产品特性
- A DNA sequence encoding the mature form of human Prss8 (NP_002764.1) (Ala 30-Arg 322) was fused with a signal peptide at the N-terminus and a polyhistidine-tag at the C-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate Boc-QAR-AMC (R&D Systems, Catalog # ES014). The specific activity is >10 pmoles/min/μg.
- Top Product
- Discover our top product PRSS8 蛋白
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Protease, serine, 8 (PRSS8) (AA 1-343) protein (GST tag)
PRSS8 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protease, serine, 8 (PRSS8) (AA 33-131) protein (GST tag)PRSS8 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protease, serine, 8 (PRSS8) (AA 30-289) protein (His tag)PRSS8 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 97 % as determined by SDS-PAGE
Protease, serine, 8 (PRSS8) (AA 33-343) protein (rho-1D4 tag)Crystallography grade PRSS8 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protease, serine, 8 (PRSS8) (AA 45-322) protein (rho-1D4 tag)Crystallography grade PRSS8 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protease, serine, 8 (PRSS8) (AA 33-322) protein (rho-1D4 tag)Crystallography grade PRSS8 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Protease, serine, 8 (PRSS8) (AA 45-322) protein (rho-1D4 tag)Crystallography grade PRSS8 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PRSS8 (Protease, serine, 8 (PRSS8))
- 别名
- Prostasin/PRSS8 (PRSS8 产品)
- 别名
- CAP1 Protein, PROSTASIN Protein, prostasin Protein, 2410039E18Rik Protein, AI313909 Protein, C79772 Protein, fr Protein, mCAP1 Protein, protease, serine 8 Protein, protease, serine, 8 Protein, protease, serine 8 (prostasin) Protein, PRSS8 Protein, Prss8 Protein
- 背景
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Background: Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.
Synonym: CAP1,PROSTASIN
- 分子量
- 32.8 kDa
- NCBI登录号
- NP_002764
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