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PARM1 Protein (His tag)

PARM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 85 % as determined by reducing SDS-PAGE.
产品编号 ABIN7317193
发货至: 中国
  • 抗原 See all PARM1 蛋白
    PARM1 (Prostate Androgen-Regulated Mucin-Like Protein 1 (PARM1))
    蛋白类型
    Recombinant
    宿主
    • 2
    • 2
    资源
    • 4
    HEK-293 Cells
    标记
    This PARM1 protein is labelled with His tag.
    原理
    Recombinant Human PARM1/PARM-1 Protein (His Tag)
    序列
    Met 1-Ser258
    产品特性
    A DNA sequence encoding the human PARM1 (AAH13294.1) (Met1-Ser258) was expressed with a polyhistidine tag at the C-terminus.
    纯度
    > 85 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product PARM1 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    PARM1 (Prostate Androgen-Regulated Mucin-Like Protein 1 (PARM1))
    别名
    PARM1/PARM-1 (PARM1 产品)
    别名
    DKFZP564O0823 Protein, DKFZp564O0823 Protein, PARM-1 Protein, 2210012L08Rik Protein, 9130213B05Rik Protein, W91666 Protein, Cipar1 Protein, WSC4 Protein, CIPAR-1 Protein, prostate androgen-regulated mucin-like protein 1 Protein, PARM1 Protein, Parm1 Protein
    背景

    Background: Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-bound calcium (through a calcium release channel) triggers muscle contraction. The active protein is not highly structured, more than 50 % of it adopting a random coil conformation. When calcium binds there is a structural change whereby the alpha-helical content of the protein increases from 3 to 11 %. Both forms of calsequestrin are phosphorylated by casein kinase 2, but the cardiac form is phosphorylated more rapidly and to a higher degree. Calsequestrin-1 is also secreted in the gut where it deprives bacteria of calcium ions.

    Synonym: Cipar1,DKFZP564O0823,PARM-1,WSC4

    分子量
    25.7 kDa
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