PTGS2 Protein (His tag)
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- 抗原 See all PTGS2 蛋白
- PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This PTGS2 protein is labelled with His tag.
- 原理
- Recombinant Human PTGS2/COX2/PGHS-2 Protein (His Tag)
- 序列
- Met 1-Leu 604
- 产品特性
- A DNA sequence encoding the human PTGS2 (NP_000954.1) (Met 1-Leu 604) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PTGS2 蛋白
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Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 1-604) protein (GST tag)
PTGS2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 18-604) protein (His tag)Crystallography grade PTGS2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 18-604) protein (His tag)Crystallography grade PTGS2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) (AA 18-601), (partial) protein (His tag)PTGS2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) proteinPTGS2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 10 % glycerol, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))
- 别名
- PTGS2/COX2/PGHS-2 (PTGS2 产品)
- 别名
- COX-2 Protein, COX2 Protein, GRIPGHS Protein, PGG/HS Protein, PGHS-2 Protein, PHS-2 Protein, hCox-2 Protein, Cox-2 Protein, Pghs2 Protein, TIS10 Protein, Cox2 Protein, cox-2 Protein, CEF147 Protein, PGHS2 Protein, PHSII Protein, cox2 Protein, gripghs Protein, pgg/hs Protein, pghs-2 Protein, phs-2 Protein, PTGS2 Protein, hcox-2 Protein, fj02a10 Protein, ptgs2 Protein, unp1239 Protein, wu:fj02a10 Protein, zCOX-2 Protein, si:dkey-97o5.6 Protein, prostaglandin-endoperoxide synthase 2 Protein, prostaglandin G/H synthase 2 Protein, prostaglandin-endoperoxide synthase 2S homeolog Protein, prostaglandin-endoperoxide synthase 2a Protein, prostaglandin-endoperoxide synthase 2b Protein, PTGS2 Protein, Ptgs2 Protein, LOC100136456 Protein, ptgs2.S Protein, ptgs2 Protein, ptgs2a Protein, ptgs2b Protein
- 背景
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Background: PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is over expressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Synonym: COX-2,COX2,GRIPGHS,hCox-2,PGG/HS,PGHS-2,PHS-2
- 分子量
- 68.5 kDa
- NCBI登录号
- NP_000954
- 途径
- Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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