PIGR Protein (His tag)
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- 抗原 See all PIGR 蛋白
- PIGR (Polymeric Immunoglobulin Receptor (PIGR))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 人细胞
- 标记
- This PIGR protein is labelled with His tag.
- 原理
- Recombinant Human PIGR Protein (His Tag)
- 序列
- Lys19-Arg638
- 产品特性
- Recombinant Human Polymeric Immunoglobulin Receptor is produced by our Mammalian expression system and the target gene encoding Lys19-Arg638 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PIGR 蛋白
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Polymeric Immunoglobulin Receptor (PIGR) (AA 21-130) protein (GST tag)
PIGR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Polymeric Immunoglobulin Receptor (PIGR) (Active) protein (His tag)PIGR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PIGR (Polymeric Immunoglobulin Receptor (PIGR))
- 别名
- PIGR (PIGR 产品)
- 别名
- DKFZp469G1013 Protein, RNPIGR2 Protein, pIgA-R Protein, polymeric immunoglobulin receptor Protein, PIGR Protein, Pigr Protein
- 背景
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Background: The human Polymeric Immunoglobulin Receptor (pIgR) is a 100 kDa type I transmembrane glycoprotein. Its precursor is 764 amino acids. It contains an 18 amino acid signal sequence, a 620 amino acid extracellular region, a 23 amino acid transmembrane fragment, and a 103 amino acid cytoplasmic domain. pIgR is synthesized by secretory epithelial cells with five Ig-like domains in extracellular region, and transfer to the basolateral plasma membrane. For IgA and IgM polymers, in addition to α-heavy chains and light Ig chains, a short polypeptide named joining chain (J chain) is also contained and required. pIgR can bind larger polymers of IgA (pIgA) and pentameric IgM as a carrier that transports IgA and IgM across epithelium. The receptor-ligand complexes are endocytosed and transcytosed to the apical surface, then proteolytic cleavage of the sixth extracellular domain of pIgR and generate secretory IgA (SIgA), the pIgR fragment is referred to as secretory component (SC). SIgA is a important component of the mucosal immune system. SC is anti-microbial properties and protects SIgA from proteolytic degradation
Synonym: Polymeric Immunoglobulin Receptor, PIgR, Poly-Ig Receptor, Hepatocellular Carcinoma-Associated Protein TB6, PIGR
- 分子量
- 68.9 kDa
- NCBI登录号
- NP_002635
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