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PLA2G2D Protein (Fc Tag)

PLA2G2D 宿主: 人 宿主: HEK-293 Cells Recombinant > 85 % as determined by reducing SDS-PAGE.
产品编号 ABIN7197351
发货至: 中国
  • 抗原 See all PLA2G2D 蛋白
    PLA2G2D (Phospholipase A2, Group IID (PLA2G2D))
    蛋白类型
    Recombinant
    宿主
    • 4
    • 3
    • 1
    资源
    • 5
    • 2
    • 1
    HEK-293 Cells
    标记
    This PLA2G2D protein is labelled with Fc Tag.
    原理
    Recombinant Human PLA2G2D Protein (Fc Tag)
    序列
    Met 1-Cys145
    产品特性
    A DNA sequence encoding the human PLA2G2D (Q9UNK4) (Met1-Cys145) was expressed with the Fc region of human IgG1 at the C-terminus.
    纯度
    > 85 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product PLA2G2D 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    PLA2G2D (Phospholipase A2, Group IID (PLA2G2D))
    别名
    PLA2G2D (PLA2G2D 产品)
    别名
    PLA2IID Protein, SPLASH Protein, sPLA2-IID Protein, sPLA2S Protein, Splash Protein, mGIID Protein, phospholipase A2 group IID Protein, phospholipase A2, group IID Protein, PLA2G2D Protein, Pla2g2d Protein
    背景

    Background: The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48- kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST/OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto the asparagine acceptor site within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains across the membrane of the endoplasmic reticulum. The mammalian oligosaccharyltransferase (OST) is an oligomeric complex composed of three type I transmembrane proteins of the endoplasmic reticulum: ribophorin I (RI), ribophorin II (RII), and OST48. OST48 is not a glycoprotein and is not recognized by antibodies to either ribophorin. Like ribophorins I and II, OST48 was found to be an integral membrane protein, with the majority of the polypeptide located within the lumen of the endoplasmic reticulum (ER). OST48 does not show significant amino acid sequence homology to either ribophorin I or II. It had been found that only the luminal domain of RI contains ER retention information. The dilysine motif in OST48 functions as an ER localization motif because OST48 in which the two lysine residues are replaced by serine (OST48ss) is no longer retained in the ER and is found instead also at the plasma membrane.

    Synonym: PLA2IID,sPLA2-IID,sPLA2S,SPLASH

    分子量
    41.5 kDa
    UniProt
    Q9UNK4
    途径
    Inositol Metabolic Process
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