OXSR1 Protein (GST tag)
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- 抗原 See all OXSR1 蛋白
- OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This OXSR1 protein is labelled with GST tag.
- 原理
- Recombinant Human OXSR1/OSR1 Protein (GST Tag)
- 序列
- Met 1-Ser 527
- 产品特性
- A DNA sequence encoding the full length of human OXSR1 (NP_005100.1) (Met 1-Ser 527) was fused with the GST tag at the N-terminus.
- 纯度
- > 88 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product OXSR1 蛋白
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Oxidative-Stress Responsive 1 (OXSR1) (AA 1-527) protein (GST tag)
OXSR1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA, KAA
Oxidative-Stress Responsive 1 (OXSR1) (AA 351-450) protein (GST tag)OXSR1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Oxidative-Stress Responsive 1 (OXSR1) (AA 1-527) protein (His tag)OXSR1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Oxidative-Stress Responsive 1 (OXSR1) protein (Myc-DYKDDDDK Tag)OXSR1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 0.5 mM GSH, 0.5 mM PMSF, 0.5 mM EDTA, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))
- 别名
- OXSR1/OSR1 (OXSR1 产品)
- 别名
- OSR1 Protein, C20orf111 Protein, HSPC207 Protein, Osr1 Protein, Perit1 Protein, dJ1183I21.1 Protein, zgc:55494 Protein, zgc:77321 Protein, OXSR1 Protein, 2210022N24Rik Protein, 2810422B09Rik Protein, AI462649 Protein, AW209236 Protein, mKIAA1101 Protein, odd1 Protein, osr1 Protein, wu:fb77f12 Protein, zgc:165661 Protein, oxidative stress responsive 1 Protein, oxidative stress responsive serine rich 1 Protein, oxidative stress responsive 1b Protein, serine/threonine-protein kinase OSR1 Protein, odd-skipped related transciption factor 1 Protein, oxidative-stress responsive 1 Protein, oxidative stress responsive 1a Protein, OXSR1 Protein, OSER1 Protein, oxsr1b Protein, CpipJ_CPIJ015177 Protein, Tsp_00299 Protein, OSR1 Protein, Oxsr1 Protein, LOC106505565 Protein, oxsr1 Protein, oxsr1a Protein
- 背景
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Background: Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39 % identical to that of human SOK1. Of potential regulators surveyed, endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 did not increase the activity of coexpressed JNK, nor did it activate three other MAPKs, p38, ERK2, and ERK5. Phosphorylation by OXSR1 modulates the G protein sensitivity of PAK isoforms. The OXSR1 and SPAK are key enzymes in a signalling cascade regulating the activity of Na+/K+/2Cl- co-transporters (NKCCs) in response to osmotic stress. Both kinases have a conserved carboxy-terminal (CCT) domain, which recognizes a unique peptide (Arg-Phe-Xaa-Val) motif. The OXSR1 and SPAK kinases specifically recognize their upstream activators and downstream substrates.
Synonym: OSR1
- 分子量
- 84 kDa
- NCBI登录号
- NP_005100
- 途径
- Tube Formation
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