OSTM1 Protein (His tag)
-
- 抗原 See all OSTM1 蛋白
- OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))
- 蛋白类型
- Recombinant
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This OSTM1 protein is labelled with His tag.
- 原理
- Recombinant Human OSTM1 Protein (His Tag)
- 序列
- Met 1-Pro 284
- 产品特性
- A DNA sequence encoding the extracellular domain of human OSTM1 (NP_054747.2) (Met 1-Pro 284) was expressed, fused with a C-terminal polyhistidine tag.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product OSTM1 蛋白
-
Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 183-282) protein (GST tag)
OSTM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 32-284) protein (His tag)Crystallography grade OSTM1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 35-288) protein (His tag)Crystallography grade OSTM1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 32-334) protein (rho-1D4 tag)Crystallography grade OSTM1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) (AA 35-338) protein (rho-1D4 tag)Crystallography grade OSTM1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) protein (Myc-DYKDDDDK Tag)OSTM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))
- 别名
- OSTM1 (OSTM1 产品)
- 别名
- MGC145644 Protein, si:ch73-257c13.3 Protein, GIPN Protein, GL Protein, OPTB5 Protein, 1200002H13Rik Protein, HSPC019 Protein, gl Protein, Gipn Protein, OSTM1 Protein, osteopetrosis associated transmembrane protein 1 Protein, OSTM1 Protein, ostm1 Protein, Ostm1 Protein
- 背景
-
Background: Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has a important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).
Synonym: GIPN;GL;HSPC019;OPTB5
- 分子量
- 29.7 kDa
- NCBI登录号
- NP_054747
-
