OMG Protein (AA 1-416) (His tag)
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- 抗原 See all OMG 蛋白
- OMG (Oligodendrocyte Myelin Glycoprotein (OMG))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 1-416
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This OMG protein is labelled with His tag.
- 原理
- Recombinant Human OMGP/OMG Protein (aa 1-416, His Tag)(Active)
- 序列
- Met 1-Pro 416
- 产品特性
- A DNA sequence encoding the mature form of human OMGP (P23515-1) (Met 1-Pro 416) without the pro peptide was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. Immobilized OMG (0.8 μg/ml, 100 μl/well) will mediate >15% C6 cell adhesion.
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Oligodendrocyte Myelin Glycoprotein (OMG) (AA 25-417) protein (His tag)Crystallography grade OMG 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- OMG (Oligodendrocyte Myelin Glycoprotein (OMG))
- 别名
- OMGP/OMG (OMG 产品)
- 别名
- OMGP Protein, omgp Protein, MGC107958 Protein, OMG Protein, DKFZp459F1351 Protein, oligodendrocyte myelin glycoprotein Protein, myelin oligodendrocyte glycoprotein Protein, oligodendrocyte-myelin glycoprotein Protein, OMG Protein, MOG Protein, Omg Protein, omg Protein
- 背景
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Background: Oligodendrocyte-myelin glycoprotein; also known as OMG and OMGP; is a cell membrane protein which contains eight LRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR; the receptor for Nogo. This function requires its leucine-rich repeat domain; a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation; neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.
Synonym: OMGP
- 分子量
- 46 kDa
- 途径
- Neurotrophin Signaling Pathway, Regulation of Cell Size
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