NRP2 Protein (His tag)
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- 抗原 See all NRP2 蛋白
- NRP2 (Neuropilin 2 (NRP2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This NRP2 protein is labelled with His tag.
- 原理
- Recombinant Human Neuropilin-2/NRP2 Protein (His Tag)(Active)
- 序列
- Met 1-Tyr 855
- 产品特性
- A DNA sequence encoding the extracellular domain (Met 1-Tyr 855) ofhuman Neurophilin2 isoform 2 (NP_003863.2) was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.
- Top Product
- Discover our top product NRP2 蛋白
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Neuropilin 2 (NRP2) (AA 23-859) protein (His tag)
NRP2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Neuropilin 2 (NRP2) (AA 23-859) protein (His tag)NRP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Neuropilin 2 (NRP2) (AA 22-131) protein (GST tag)NRP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Neuropilin 2 (NRP2) (AA 621-715) protein (GST tag)NRP2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- NRP2 (Neuropilin 2 (NRP2))
- 别名
- Neuropilin-2/NRP2 (NRP2 产品)
- 别名
- NP2 Protein, NPN2 Protein, PRO2714 Protein, VEGF165R2 Protein, 1110048P06Rik Protein, Np-2 Protein, Np2 Protein, Npn-2 Protein, Npn2 Protein, neuropilin-2 Protein, neuropilin 2 Protein, NRP2 Protein, Nrp2 Protein
- 背景
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Background: Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classIII semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.
Synonym: Neuropilin-2,NP2,NPN2,PRO2714,VEGF165R2
- 分子量
- 95 kDa
- NCBI登录号
- NP_003863
- 途径
- Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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