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NQO1 Protein (His tag)

NQO1 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % as determined by reducing SDS-PAGE.
产品编号 ABIN7197091
发货至: 中国
  • 抗原 See all NQO1 蛋白
    NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))
    蛋白类型
    Recombinant
    宿主
    • 5
    • 3
    • 1
    资源
    • 6
    • 1
    • 1
    • 1
    大肠杆菌(E. Coli)
    标记
    This NQO1 protein is labelled with His tag.
    原理
    Recombinant Human NQO1/DT-diaphorase Protein (His Tag)
    序列
    Met 1-Lys274
    产品特性
    A DNA sequence encoding the mature form of human NQO1 (P15559-1) (Met1-Lys274) was expressed with a polyhistide tag at the N-terminus.
    纯度
    > 90 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product NQO1 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Please refer to the printed manual for detailed information.
    缓冲液
    Lyophilized from sterile PBS, pH 7.4
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))
    别名
    NQO1/DT-diaphorase (NQO1 产品)
    别名
    zgc:77191 Protein, wu:fb63c10 Protein, nqo1 Protein, DHQU Protein, DIA4 Protein, DTD Protein, NMOR1 Protein, NMORI Protein, QR1 Protein, Dia4 Protein, AV001255 Protein, Dtd Protein, Nmo-1 Protein, Nmo1 Protein, Nmor1 Protein, Ox-1 Protein, Ox1 Protein, Qr1 Protein, NADPH-d Protein, NAD(P)H dehydrogenase, quinone 1 Protein, NAD(P)H quinone dehydrogenase 1 Protein, NAD(P)H dehydrogenase, quinone 1 L homeolog Protein, nqo1 Protein, NQO1 Protein, Bpet2092 Protein, nqo1.L Protein, Nqo1 Protein
    背景

    Background: NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.

    Synonym: DHQU,DIA4,DTD,NMOR1,NMORI,QR1

    分子量
    33 kDa
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