LDLR Protein (His tag)
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- 抗原 See all LDLR 蛋白
- LDLR (Low Density Lipoprotein Receptor (LDLR))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This LDLR protein is labelled with His tag.
- 原理
- Recombinant Mouse LDLR Protein (His Tag)(Active)
- 序列
- Met 1-Arg 790
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse LDLR (NP_034830.2) precursor (Met 1-Arg 790) with substitution of Val 23 and Gly 27 by Ala 23 and Cys 27 respectively was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Rat PCSK9 at 10 μg/ml (100 μl/well) can bind biotinylated recombinant mouse LDLR. The EC50 of biotinylated mouse LDLR is 0.173 μg/ml.
- Top Product
- Discover our top product LDLR 蛋白
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Low Density Lipoprotein Receptor (LDLR) (AA 22-788) protein (His tag)
LDLR 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) protein (His-Avi Tag)LDLR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Low Density Lipoprotein Receptor (LDLR) (AA 105-205) protein (GST tag)LDLR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) protein (His-Avi Tag,Biotin)LDLR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) (Active) protein (His tag)LDLR 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) (Active) protein (His tag)LDLR 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Low Density Lipoprotein Receptor (LDLR) (AA 455-607) protein (His-IF2DI Tag)LDLR 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Low Density Lipoprotein Receptor (LDLR) (AA 1-860) protein (GST tag)LDLR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Low Density Lipoprotein Receptor (LDLR) (AA 22-788) protein (His tag)Crystallography grade LDLR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Low Density Lipoprotein Receptor (LDLR) (AA 22-790) protein (His tag)Crystallography grade LDLR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- LDLR (Low Density Lipoprotein Receptor (LDLR))
- 别名
- LDLR (LDLR 产品)
- 别名
- FH Protein, FHC Protein, LDLCQ2 Protein, Hlb301 Protein, LDLRA Protein, LDLA Protein, LDL receptor-2 Protein, fhc Protein, ldlcq2 Protein, ldlr Protein, ldlr2-a Protein, LDL receptor 1 Protein, ldlr-a Protein, ldlr-b Protein, low density lipoprotein receptor Protein, low density lipoprotein receptor a Protein, low density lipoprotein receptor S homeolog Protein, low density lipoprotein receptor L homeolog Protein, LDLR Protein, Ldlr Protein, ldlra Protein, ldlr.S Protein, ldlr.L Protein
- 背景
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Background: LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.
Synonym: Hlb301
- 分子量
- 85.7 kDa
- NCBI登录号
- NP_034830
- 途径
- Hepatitis C, Lipid Metabolism
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