LTC4S Protein (His tag)
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- 抗原 See all LTC4S 蛋白
- LTC4S (Leukotriene C4 Synthase (LTC4S))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This LTC4S protein is labelled with His tag.
- 原理
- Recombinant Human LTC4S/LTC4 synthase Protein (His Tag)
- 序列
- Met 1-Ala 150
- 产品特性
- A DNA sequence encoding the human LTC4S (NP_665874.1) (Met 1-Ala 150) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product LTC4S 蛋白
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Leukotriene C4 Synthase (LTC4S) (AA 1-150) protein (GST tag)
LTC4S 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Leukotriene C4 Synthase (LTC4S) (AA 1-150) protein (Strep Tag)Crystallography grade LTC4S 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Leukotriene C4 Synthase (LTC4S) (AA 1-150) protein (Strep Tag)Crystallography grade LTC4S 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Leukotriene C4 Synthase (LTC4S) protein (Myc-DYKDDDDK Tag)LTC4S 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Hepes, 0.1 % Triton 0.5 % DOC, 10 % glycerol, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- LTC4S (Leukotriene C4 Synthase (LTC4S))
- 别名
- LTC4S/LTC4 synthase (LTC4S 产品)
- 别名
- LTC4S Protein, ltc4s Protein, si:dkey-33h4.2 Protein, leukotriene C4 synthase Protein, leukotriene C4 synthase-like Protein, leukotriene C4 synthase, gene 1 Protein, Ltc4s Protein, LTC4S Protein, LTC4SL Protein, ltc4s.1 Protein, ltc4s Protein
- 背景
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Background: Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein which belongs to the MAPEG family. LTC4S is detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. LTC4S is essential for the production of cysteinyl leukotrienes (Cys-LT), critical mediators in asthma. Mutagenic analysis of the conjugation function of human LTC4S has identified R51 and Y93 as critical for acid and base catalysis of LTA4 and reduced glutathione, respectively. A comparison across species for proteins that possess LTC4S activity reveals conservation of both of these residues, whereas R51 is absent in the FLAP molecules. Thus, within the glutathione S-transferase superfamily of genes, alignment of specific residues allows the separation of LTC4S family members from their most structurally similar counterparts, the FLAP molecules. Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency). LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
Synonym: LTC4S;MGC33147
- 分子量
- 17 kDa
- NCBI登录号
- NP_665874
- 途径
- Cellular Response to Molecule of Bacterial Origin
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