LAMTOR2 Protein (His tag)
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- 抗原 See all LAMTOR2 蛋白
- LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This LAMTOR2 protein is labelled with His tag.
- 原理
- Recombinant Human LAMTOR2/ROBLD3/MAPBPIP Protein (His Tag)
- 序列
- Met 1-Ser 125
- 产品特性
- A DNA sequence encoding the mature form of human LAMTOR2 isoform 1 (Q9Y2Q5-1) (Met 1-Ser 125) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product LAMTOR2 蛋白
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Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2) (AA 1-125) protein (His tag)
LAMTOR2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2) (AA 1-125) protein (Strep Tag)Crystallography grade LAMTOR2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)LAMTOR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- LAMTOR2 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 2 (LAMTOR2))
- 别名
- LAMTOR2/ROBLD3/MAPBPIP (LAMTOR2 产品)
- 别名
- ENDAP Protein, HSPC003 Protein, MAPBPIP Protein, MAPKSP1AP Protein, ROBLD3 Protein, Ragulator2 Protein, p14 Protein, 2010111E04Rik Protein, AL022628 Protein, Mapbpip Protein, P14 Protein, Rab25 Protein, Robld3 Protein, RGD1562501 Protein, cg5189 Protein, endap Protein, hspc003 Protein, mapbpip Protein, mapbpip-B Protein, mapksp1ap Protein, ragulator2 Protein, robld3 Protein, robld3-b Protein, zgc:100811 Protein, lamtor2 Protein, lamtor2-a Protein, lamtor2-b Protein, mapbpip-A Protein, robld3-a Protein, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Protein, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 S homeolog Protein, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 L homeolog Protein, LAMTOR2 Protein, Lamtor2 Protein, lamtor2.S Protein, lamtor2 Protein, lamtor2.L Protein
- 背景
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Background: Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal / lysosomal Mp1-interacting protein, Late endosomal / lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP and ROBLD3, is a protein which belongs to the GAMAD family. LAMTOR2 / ROBLD3 is a regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, LAMTOR2 / ROBLD3 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. LAMTOR2 / ROBLD3 is an adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Defects in LAMTOR2 are the cause of immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP). This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.
Synonym: ENDAP;HSPC003;MAPBPIP;MAPKSP1AP;p14;Ragulator2;ROBLD3;RP11-336K24.9
- 分子量
- 15 kDa
- 途径
- PI3K-Akt Signaling
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