KIRREL Protein (His tag)
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- 抗原 See all KIRREL (NEPH1) 蛋白
- KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This KIRREL protein is labelled with His tag.
- 原理
- Recombinant Mouse KIRREL1/NEPH1 Protein (His Tag)
- 序列
- Leu48-Leu525
- 产品特性
- Recombinant Mouse KIRREL1 is produced by our Mammalian expression system and the target gene encoding Leu48-Leu525 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Kin of IRRE Like 1 (NEPH1) (Active) protein (His tag)
NEPH1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE Active
Kin of IRRE Like 1 (NEPH1) (AA 553-789) protein (His tag)Crystallography grade NEPH1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, Crys, ELISA, SDS
Kin of IRRE Like 1 (NEPH1) (AA 521-757) protein (His tag)Crystallography grade NEPH1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, Crys, ELISA, SDS
Kin of IRRE Like 1 (NEPH1) (AA 17-499) protein (His tag)Crystallography grade NEPH1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, Crys, ELISA, SDS
Kin of IRRE Like 1 (NEPH1) (AA 48-531) protein (His tag)Crystallography grade NEPH1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, Crys, ELISA, SDS
Kin of IRRE Like 1 (NEPH1) (AA 17-757) protein (rho-1D4 tag)Crystallography grade NEPH1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, Crys, ELISA, SDS
Kin of IRRE Like 1 (NEPH1) (AA 48-789) protein (rho-1D4 tag)Crystallography grade NEPH1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, Crys, ELISA, SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))
- 别名
- KIRREL1/NEPH1 (NEPH1 产品)
- 别名
- NEPH1 Protein, 6720469N11Rik Protein, Kirrel1 Protein, Neph1 Protein, nephrin related Protein, kirre like nephrin family adhesion molecule 1 Protein, kin of IRRE like (Drosophila) Protein, Smp_104390 Protein, Smp_140170 Protein, KIRREL1 Protein, Kirrel Protein, Kirrel1 Protein
- 背景
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Background: Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like protein 1(Neph1), belongs to the immunoglobulin superfamily. Kirrel1 plays a significant role in the normal development and function of the glomerular permeability. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. The knockout of this gene could result in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli. Its' subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains). This interaction is dependent on KIRREL glycosylation. Kirrel1 also interacts when tyrosine-phosphorylated with GRB2.
Synonym: Kin of IRRE-like protein 1,Kin of irregular chiasm-like protein 1,Nephrin-like protein 1,Kirrel1,Neph1
- 分子量
- 53.4 kDa
- UniProt
- Q80W68
- 途径
- Regulation of Actin Filament Polymerization
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