IFITM3 Protein (Fc Tag)
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- 抗原 See all IFITM3 蛋白
- IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IFITM3 protein is labelled with Fc Tag.
- 原理
- Recombinant Human IFITM3 Protein (Fc Tag)
- 序列
- Met 1-His57
- 产品特性
- A DNA sequence encoding the human IFITM3 (NP_066362.2) (Met1-His57) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.
- 纯度
- > 99 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product IFITM3 蛋白
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Interferon-Induced Transmembrane Protein 3 (IFITM3) (AA 1-133) protein (GST tag)
IFITM3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interferon-Induced Transmembrane Protein 3 (IFITM3) (AA 1-133) protein (His-IF2DI Tag)IFITM3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interferon-Induced Transmembrane Protein 3 (IFITM3) (AA 1-133) protein (Strep Tag)Crystallography grade IFITM3 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
Interferon-Induced Transmembrane Protein 3 (IFITM3) (AA 1-137) protein (Strep Tag)Crystallography grade IFITM3 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))
- 别名
- IFITM3 (IFITM3 产品)
- 别名
- 1110004C05Rik Protein, Cd225 Protein, Cdw217 Protein, DSPA2b Protein, Fgls Protein, IP15 Protein, mil-1 Protein, 1-8U Protein, rat8 Protein, Interferon-induced transmembrane protein 3 Protein, interferon induced transmembrane protein 3 Protein, ifm3 Protein, Ifitm3 Protein, IFITM3 Protein
- 背景
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Background: Interferon-induced transmembrane protein 3 (IFITM3) belongs to the CD225 family. To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The interferon inducible transmembrane protein family members, IFITM1, 2 and 3, are IEGs required for inhibition of influenza A virus, dengue virus, and West Nile virus replication in vitro. IFITM3 is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. It is both necessary and sufficient for preventing the emergence of viral genomes from the endosomal pathway. Viral pseudoparticles were inhibited from transferring their contents into the host cell cytosol by IFN, and IFITM3 was required and sufficient for this action. IFITM3 overexpression is sufficient for this phenotype. Moreover, IFITM3 partially resides in late endosomal and lysosomal structures, placing it in the path of invading viruses.
Synonym: 1-8U,DSPA2b,IP15
- 分子量
- 32.9 kDa
- NCBI登录号
- NP_066362
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