HPGD Protein (His tag)
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- 抗原 See all HPGD 蛋白
- HPGD (Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This HPGD protein is labelled with His tag.
- 原理
- Recombinant Human 15-PGDH Protein (His Tag)(Active)
- 序列
- Met 1-Gln 266
- 产品特性
- A DNA sequence encoding the human HPGD (NP_000851.2) (Met 1-Gln 266) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- Measured by the production of NADH during the oxidation of PGF2α. The specific activity is >1,500 pmoles/min/μg.
- Top Product
- Discover our top product HPGD 蛋白
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Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) (AA 1-266) protein (GST tag)
HPGD 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) (Active) protein (His tag)HPGD 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >90 % as determined by reducing SDS-PAGE. Active
Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) (AA 1-266) protein (His tag)HPGD 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) (AA 1-269) protein (Strep Tag)Crystallography grade HPGD 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) (AA 1-269) protein (His tag)HPGD 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % by SDS - PAGE SDS
Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)HPGD 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM DTT, 10 % glycerol, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- HPGD (Hydroxyprostaglandin Dehydrogenase 15-(NAD) (HPGD))
- 别名
- 15-PGDH (HPGD 产品)
- 别名
- CBR Protein, SDR21C1 Protein, hCBR1 Protein, 15-PGDH Protein, PGDH Protein, PGDH1 Protein, PHOAR1 Protein, SDR36C1 Protein, MGC80546 Protein, MGC79454 Protein, AV026552 Protein, carbonyl reductase 1 Protein, 15-hydroxyprostaglandin dehydrogenase Protein, hydroxyprostaglandin dehydrogenase 15-(NAD) Protein, 15-hydroxyprostaglandin dehydrogenase L homeolog Protein, hydroxyprostaglandin dehydrogenase 15 (NAD) Protein, CBR1 Protein, HPGD Protein, hpgd.L Protein, hpgd Protein, pgdh Protein, Hpgd Protein, PTRG_03214 Protein, VDBG_09957 Protein
- 背景
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Background: 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) , cranioosteoarthropathy (COA), and isolated congenital nail clubbing.
Synonym: 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)]; 15-PGDH; Prostaglandin Dehydrogenase 1; HPGD; PGDH1;PGDH;PHOAR1;SDR36C1
- 分子量
- 29.7 kDa
- NCBI登录号
- NP_000851
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