HFE2 Protein (His tag)
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- 抗原 See all HFE2 蛋白
- HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This HFE2 protein is labelled with His tag.
- 原理
- Recombinant Human Hemojuvelin/HFE2 Protein (His Tag)
- 序列
- Met 1-Ser 399
- 产品特性
- A DNA sequence encoding the mature form of human HFE2 isoform a (Q6ZVN8-1) (Met 1-Ser 399) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product HFE2 蛋白
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Hemochromatosis Type 2 (Juvenile) (HFE2) (AA 93-173) protein (GST tag)
HFE2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Hemochromatosis Type 2 (Juvenile) (HFE2) (AA 36-400) protein (His tag)Crystallography grade HFE2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Hemochromatosis Type 2 (Juvenile) (HFE2) (AA 33-393) protein (His tag)Crystallography grade HFE2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Hemochromatosis Type 2 (Juvenile) (HFE2) protein (Ovalbumin)HFE2 宿主: 人 宿主: 合成 Synthetic > 95 % WB, SDS, ELISA, IP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, 500 mM NaCl, pH 7.0, 10 % gly
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))
- 别名
- Hemojuvelin/HFE2 (HFE2 产品)
- 别名
- HFE2A Protein, HJV Protein, JH Protein, RGMC Protein, HFE2 Protein, DKFZp468F2322 Protein, 2310035L15Rik Protein, 5230400G09Rik Protein, AI414844 Protein, AI789733 Protein, DL-M Protein, Rgmc Protein, hemojuvelin Protein, RGMr Protein, hjv Protein, id:ibd3464 Protein, wu:fb38f10 Protein, zgc:136698 Protein, hemochromatosis type 2 (juvenile) Protein, hemochromatosis type 2 Protein, HFE2 Protein, Hfe2 Protein, hfe2 Protein
- 背景
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Background: Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).
Synonym: HFE2A,HJV,JH,RGMC
- 分子量
- 40 kDa
- 途径
- Transition Metal Ion Homeostasis
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