Hsc70 Protein (His tag)
-
- 抗原 See all Hsc70 (HSPA8) 蛋白
- Hsc70 (HSPA8) (Heat Shock 70kDa Protein 8 (HSPA8))
- 蛋白类型
- Recombinant
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 标记
- This Hsc70 protein is labelled with His tag.
- 原理
- Recombinant Human HSPA8/HSC70 Protein (His Tag)
- 序列
- Met 1-Asp 646
- 产品特性
- A DNA sequence encoding the human HSPA8 (P11142-1) (Met 1-Asp 646) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product HSPA8 蛋白
-
Heat Shock 70kDa Protein 8 (HSPA8) (AA 1-646) protein (GST tag)
HSPA8 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Heat Shock 70kDa Protein 8 (HSPA8) (AA 359-646) protein (His tag)HSPA8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Heat Shock 70kDa Protein 8 (HSPA8) (AA 1-646) protein (His tag)HSPA8 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS-PAGE SDS
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, 10 % glycerol, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- Hsc70 (HSPA8) (Heat Shock 70kDa Protein 8 (HSPA8))
- 别名
- HSPA8/HSC70 (HSPA8 产品)
- 别名
- hsc54 Protein, hsc70 Protein, hsc71 Protein, hsp71 Protein, hsp73 Protein, hspa10 Protein, lap1 Protein, nip71 Protein, HSC54 Protein, HSC70 Protein, HSC71 Protein, HSP71 Protein, HSP73 Protein, HSPA10 Protein, LAP1 Protein, NIP71 Protein, Hsc70 Protein, 2410008N15Rik Protein, Hsc71 Protein, Hsc73 Protein, Hsp73 Protein, Hspa10 Protein, wu:fb01g06 Protein, wu:fi48b06 Protein, heat shock protein family A (Hsp70) member 8 L homeolog Protein, heat shock protein family A (Hsp70) member 8 Protein, heat shock 70kDa protein 8 Protein, heat shock protein 8 Protein, hspa8.L Protein, HSPA8 Protein, Hspa8 Protein, hspa8 Protein
- 背景
-
Background: HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised by both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common, but vary in the extent of their inducibility in response to metabolic stress. HSPA8 is constitutively expressed and performs functions related to normal cellular processes. This protein binds to nascent polypeptides to facilitate correct protein folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date. HSPA8 acts as a repressor of transcriptional activation. It inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones. It also is a ATPase that works with auxilin to remove clathrin coated vesicles. In neurons, synaptojanin is also an important protein involved in vesicle uncoating.
Synonym: HEL-33,HEL-S-72p,HSC54,HSC70,HSC71,HSP71,HSP73,HSPA10,LAP-1,LAP1,NIP71
- 分子量
- 72.4 kDa
-
