GBP1 Protein (His tag)
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- 抗原 See all GBP1 蛋白
- GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This GBP1 protein is labelled with His tag.
- 原理
- Recombinant Human GBP1 Protein (His Tag)
- 序列
- Met 1-Cys 589
- 产品特性
- A DNA sequence encoding the human GBP1 (AAA35871.1) (Met 1-Cys 589) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product GBP1 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))
- 别名
- GBP1 (GBP1 产品)
- 别名
- guanylate binding protein 1 Protein, guanylate binding protein 1, interferon-inducible Protein, guanylate binding protein 1, interferon-inducible, 67kD Protein, GBP1 Protein, Gbp1 Protein, gbp1 Protein
- 背景
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Background: Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secretion occurred without the presence of a leader peptide. Secretion procession is a nonclassical, likely ABC transporter-dependent, pathway and independent of GBP-1 GTPase activity and isoprenylation, and did not require additional interferon-λ-induced factors. Clinically most important was the detection of significantly increased GBP-1 concentrations in the cerebrospinal fluid of patients with bacterial meningitis as compared to control patients.
Synonym: GBP1
- 分子量
- 69 kDa
- 途径
- Cellular Response to Molecule of Bacterial Origin
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