GZMH Protein (His tag)
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- 抗原 See all GZMH 蛋白
- GZMH (Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH))
- 蛋白类型
- Recombinant
- 宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This GZMH protein is labelled with His tag.
- 原理
- Recombinant Human Granzyme H Protein (His Tag)
- 序列
- Met 1-Leu 246
- 产品特性
- A DNA sequence encoding the human Granzyme H (NP_219491.1) (Met 1-Leu 246) with a C-terminal polyhistidine tag was expressed.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product GZMH 蛋白
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Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) (AA 1-246) protein (GST tag)
GZMH 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) (AA 147-246) protein (GST tag)GZMH 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) (AA 161-246) protein (GST tag)GZMH 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH) (AA 19-246) protein (His tag)GZMH 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- GZMH (Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH))
- 别名
- Granzyme H (GZMH 产品)
- 别名
- GZMH Protein, CCP-X Protein, CGL-2 Protein, CSP-C Protein, CTLA1 Protein, CTSGL2 Protein, granzyme H Protein, LOC617313 Protein, GZMH Protein
- 背景
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Background: Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural?killer (NK) compartment of the immune system. In adenovirus-infected cells in which granzyme B (gzmB) and downstream apoptosis pathways are inhibited, granzyme H directly cleaves the adenovirus DNA-binding protein (DBP), a viral component absolutely required for viral DNA replication. This virus demonstrated that gzmH directly induces an important decay in viral DNA replication. Interestingly, gzmH also cleaves the adenovirus 100K assembly protein, a major inhibitor of gzmB, and relieves gzmB inhibition. Granzyme H has a very high amino acid identity (>90%) with many portions of the granzyme B sequence, particularly near the amino terminus of the molecule despite performing a distinct enzymic function.
Synonym: CCP-X;CGL-2;CSP-C;CTLA1;CTSGL2;GZMH
- 分子量
- 26.7 kDa
- NCBI登录号
- NP_219491
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