GLIPR1 Protein (His tag)
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- 抗原 See all GLIPR1 蛋白
- GLIPR1 (GLI Pathogenesis-Related 1 (GLIPR1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This GLIPR1 protein is labelled with His tag.
- 原理
- Recombinant Mouse GLIPR1 Protein (His Tag)
- 序列
- Met1-Thr223
- 产品特性
- A DNA sequence encoding the mouse GLIPR1 (NP_082884.1) (Met1-Thr223) was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 85 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product GLIPR1 蛋白
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GLI Pathogenesis-Related 1 (GLIPR1) (AA 23-99) protein (GST tag)
GLIPR1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- GLIPR1 (GLI Pathogenesis-Related 1 (GLIPR1))
- 别名
- GLIPR1 (GLIPR1 产品)
- 别名
- CRISP7 Protein, GLIPR Protein, RTVP1 Protein, 2410114O14Rik Protein, RTVP-1 Protein, mRTVP-1 Protein, GLIPR1 Protein, zgc:65887 Protein, GLI pathogenesis related 1 Protein, GLI pathogenesis-related 1 Protein, GLI pathogenesis-related 1 (glioma) Protein, GLI pathogenesis-related 1b Protein, GLIPR1 Protein, Glipr1 Protein, glipr1b Protein
- 背景
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Background: Glioma pathogenesis-related protein 1, also known as Protein RTVP-1, GLIPR1 and GLIPR, is a single-pass membrane protein which belongs to the CRISP family. GLIPR1 / RTVP-1 was expressed in high levels in glioblastomas, whereas its expression in low-grade astrocytomas and normal brains was very low. Transfection of glioma cells with small interfering RNAs targeting GLIPR1 / RTVP-1 decreased cell proliferation in all the cell lines examined and induced cell apoptosis in some of them. Overexpression of GLIPR1 / RTVP-1 increased astrocyte and glioma cell proliferation and the anchorage-independent growth of the cells. In addition, overexpression of GLIPR1 / RTVP-1 rendered glioma cells more resistant to the apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand and serum deprivation. GLIPR1 / RTVP-1 regulated the invasion of glioma cells was evident by their enhanced migration through Matrigel and by their increased invasion in a spheroid confrontation assay. The increased invasive potential of the GLIPR1 / RTVP-1 overexpressors was also shown by the increased activity of matrix metalloproteinase 2 in these cells. The expression of GLIPR1 / RTVP-1 is correlated with the degree of malignancy of astrocytic tumors and that GLIPR1 / RTVP-1 is involved in the regulation of the growth, survival, and invasion of glioma cells. GLIPR1 / RTVP-1 is a potential therapeutic target in gliomas.
Synonym: 2410114O14Rik;mRTVP-1;RTVP-1;RTVP1
- 分子量
- 25.1 kDa
- NCBI登录号
- NP_082884
- 途径
- Regulation of Lipid Metabolism by PPARalpha
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