GRK6 Protein (GST tag,His tag)
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- 抗原 See all GRK6 蛋白
- GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This GRK6 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human GRK6/GPRK6 Protein (His & GST Tag)(Active)
- 序列
- Met 1-Arg 589
- 产品特性
- A DNA sequence encoding the human GRK6 isofrom B (P43250-2) (Met 1-Arg 589) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 93 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 7 nmol/min/mg using casein as substrate.
- Top Product
- Discover our top product GRK6 蛋白
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G Protein-Coupled Receptor Kinase 6 (GRK6) (AA 1-560) (Active) protein
GRK6 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
G Protein-Coupled Receptor Kinase 6 (GRK6) (AA 71-170) protein (GST tag)GRK6 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
G Protein-Coupled Receptor Kinase 6 (GRK6) (AA 1-589) protein (GST tag)GRK6 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
G Protein-Coupled Receptor Kinase 6 (GRK6) (AA 1-576) protein (Strep Tag)Crystallography grade GRK6 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
G Protein-Coupled Receptor Kinase 6 (GRK6) (AA 1-576) protein (Strep Tag)Crystallography grade GRK6 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
G Protein-Coupled Receptor Kinase 6 (GRK6) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)GRK6 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, 0.5 mM PMSF, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- GRK6 (G Protein-Coupled Receptor Kinase 6 (GRK6))
- 别名
- GRK6/GPRK6 (GRK6 产品)
- 别名
- MGC83187 Protein, GRK6 Protein, GPRK6 Protein, Gprk6 Protein, G protein-coupled receptor kinase 6 Protein, G protein-coupled receptor kinase 6 S homeolog Protein, GRK6 Protein, grk6.S Protein, grk6 Protein, Grk6 Protein
- 背景
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Background: G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6 and GPRK6, is a lipid-anchor protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK subfamily. GRK6 / GPRK6 contains one AGC-kinase C-terminal domain, one protein kinase domain and one RGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described. GRK6 / GPRK6 is widely expressed. GRK6 / GPRK6 silencing causes suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation associated with reduction in MCL1 levels and phosphorylation, illustrating a potent mechanism for the cytotoxicity of GRK6 inhibition in multiple myeloma (MM) tumor cells. GRK6 also appears to be involved in responses to morphine. Inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.
Synonym: GPRK6
- 分子量
- 95.1 kDa
- 途径
- Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Negative Regulation of Transporter Activity
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