FKBP1A Protein (His tag)
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- 抗原 See all FKBP1A 蛋白
- FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 大肠杆菌（E. Coli）
- 标记
- This FKBP1A protein is labelled with His tag.
- 原理
- Recombinant Mouse FKBP12 Protein (His Tag)
- 序列
- Gly 2-Glu 108
- 产品特性
- A DNA sequence encoding the mouse FKBP1A (NP_032045.1) (Gly 2-Glu 108) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- Top Product
- Discover our top product FKBP1A 蛋白
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FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) protein (GST tag)
FKBP1A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) protein (His tag)FKBP1A 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) protein (His tag)FKBP1A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 1-108) (Active) protein (His tag)FKBP1A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
FK506 Binding Protein 1A, 12kDa (FKBP1A) (AA 2-108) protein (His tag)Crystallography grade FKBP1A 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))
- 别名
- FKBP12 (FKBP1A 产品)
- 别名
- 12kDa Protein, FKBP12 Protein, FKBP12-T1 Protein, FKBP12-T2 Protein, Fkbp Protein, Fkbp1 Protein, mFKBP1 Protein, mFKBP12 Protein, FKBP-12 Protein, FKBP-1A Protein, FKBP1 Protein, Rotamase Protein, Fkbp12 Protein, ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12 Protein, ATFKBP12 Protein, FK506-binding protein 12 Protein, IMMUNOPHILIN Protein, MSJ1.19 Protein, MSJ1_19 Protein, PKC12 Protein, PKCI2 Protein, PPIASE Protein, FKBP1B Protein, Fkbp2 Protein, fj02g10 Protein, zgc:73373 Protein, wu:fj02g10 Protein, FKBP1A Protein, Bmfkbp13 Protein, zgc:103752 Protein, FK506 binding protein 1a Protein, FK506 binding protein 1A Protein, FK506-binding protein Protein, FK506-binding protein 12 Protein, FK506 binding protein 1Aa Protein, FK506 binding protein 1C Protein, FK506-binding protein 59 Protein, FK506 binding protein like Protein, FK506 binding protein 1A L homeolog Protein, FK506 binding protein 1Ab Protein, Fkbp1a Protein, FKBP1A Protein, Fkbp12 Protein, FKBP12 Protein, fkbp1aa Protein, FKBP1C Protein, EHI_180160 Protein, LOC5573443 Protein, Fkbp13 Protein, FKBPL Protein, fkbp1a.L Protein, fkbp1ab Protein
- 背景
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Background: FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As a conserved molecules in many eukaryotes, FKBP12 has been characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues, and is involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP12 has attracted immense attention and its role in mediating the immunosuppressive functions. FKBP12 serves a dual role as a peptidyl-prolyl cis-trans isomerase and as a modulator of several cell signaling pathways. In one such a role, FKBP12 interacts with and regulates the functional state of the ryanodine Ca2+ channel receptor by altering protein conformation and coordinating multi-protein complex formation. Another physiological role of FKBP12 is an interactor and a regulator of the type I serine/threonine kinase receptors of TGF-beta superfamily. Current data, derived from detailed biochemical studies as well as from functional studies in various systems, suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular "gradient reader" for TGF-beta family morphogens. This aspect of FKBP12 function may be critical for cellular responsiveness to morphogenetic gradients of the TGF-beta family members during early development, serving to assure the translation of different ligand concentrations into different signaling readouts. In addition, FKBP12 may be involved in neuronal or astrocytic cytoskeletal organization and in the abnormal metabolism of tau protein in Alzheimer's disease (AD) damaged neurons.
Synonym: Fkbp;Fkbp1;FKBP12
- 分子量
- 12.7 kDa
- NCBI登录号
- NP_032045
- 途径
- Negative Regulation of Transporter Activity, Methionine Biosynthetic Process
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