FGF9 Protein (His tag)
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- 抗原 See all FGF9 (FGF-9) 蛋白
- FGF9 (FGF-9) (Fibroblast Growth Factor 9 (FGF-9))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- 大肠杆菌(E. Coli)
- 标记
- This FGF9 protein is labelled with His tag.
- 原理
- Recombinant Mouse FGF-9/FGF9 Protein (His Tag)(Active)
- 序列
- Met1-Ser208
- 产品特性
- Recombinant Mouse Fibroblast Growth Factor 9 is produced by our E.coli expression system and the target gene encoding Met1-Ser208 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 4.14 ng/ml.
- Top Product
- Discover our top product FGF-9 蛋白
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl,5 % Trehalose,1 mM EDTA,20 %glycerol,1 mM DTT, pH 8.5 .
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- FGF9 (FGF-9) (Fibroblast Growth Factor 9 (FGF-9))
- 别名
- FGF-9/FGF9 (FGF-9 产品)
- 别名
- Eks Protein, FGF-9 Protein, GAF Protein, HBFG-9 Protein, HBGF-9 Protein, SYNS3 Protein, XFGF-9 Protein, fgf9-A Protein, fibroblast growth factor 9 Protein, fibroblast growth factor 9 S homeolog Protein, Fgf9 Protein, FGF9 Protein, fgf9.S Protein
- 背景
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Background: Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98 % sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, vasculature, digestive tract, and testes .It may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Deletion of mouse FGF-9 is lethal at birth due to lung hypoplasia, and causes rhizomelia, or shortening of the proximal skeleton. An unusual constitutive dimerization of FGF 9 buries receptor interaction sites which lowers its activity, and increases heparin affinity which inhibits diffusion. A spontaneous mouse mutant, Eks, interferes with dimerization, resulting monomeric, diffusible FGF-9 that causes elbow and knee synostoses (joint fusions) due to FGF-9 misexpression in developing joints.
Synonym: Fibroblast growth factor 9,FGF-9,Glia-activating factor,GAF,heparin-binding growth factor-9,HBGF-9,Fgf9,Fgf-9
- 分子量
- 24.4 kDa
- UniProt
- P54130
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