COL18A1 Protein (His tag)
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- 抗原 See all COL18A1 蛋白
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This COL18A1 protein is labelled with His tag.
- 原理
- Recombinant Mouse COL18A1/Endostatin Protein (His Tag)
- 序列
- His1591-Lys1774
- 产品特性
- Recombinant Mouse Collagen alpha-1(XVIII) chain is produced by our Mammalian expression system and the target gene encoding His1591-Lys1774 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Collagen, Type XVIII, alpha 1 (COL18A1) (AA 1572-1754) protein (His tag)
Crystallography grade COL18A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Collagen, Type XVIII, alpha 1 (COL18A1) (AA 1591-1774) protein (His tag)Crystallography grade COL18A1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Collagen, Type XVIII, alpha 1 (COL18A1) protein (KLH)COL18A1 宿主: 人 宿主: 合成 > 95 % SDS, WB, ELISA, IP
Collagen, Type XVIII, alpha 1 (COL18A1) (Transcript Variant 2) (Active) proteinCOL18A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, PI, STD Active
Collagen, Type XVIII, alpha 1 (COL18A1) (AA 1578-1754) protein (GST tag)COL18A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Collagen, Type XVIII, alpha 1 (COL18A1) (AA 1578-1754) protein (His tag)COL18A1 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- 别名
- COL18A1/Endostatin (COL18A1 产品)
- 别名
- KNO Protein, KNO1 Protein, KS Protein, cb371 Protein, cb529 Protein, fc96d06 Protein, sb:cb529 Protein, wu:fb47h10 Protein, wu:fb77g12 Protein, wu:fc50f04 Protein, wu:fc96d06 Protein, wu:fk02h12 Protein, kno Protein, kno1 Protein, collagen type XVIII alpha 1 chain Protein, collagen type XVIII alpha 1 chain a Protein, collagen, type XVIII, alpha 1 Protein, collagen type XVIII alpha 1 Protein, COL18A1 Protein, col18a1a Protein, Col18a1 Protein, col18a1 Protein
- 物质类
- Chemical
- 背景
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Background: Endostatin, an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP-2 and MMP-9, and cathepsins S, B and L. The N-terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti-endothelial and anti-tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse Endostatin shares 96 % aa sequence identity with rat and 85-87 % with human, bovine and equine Endostatin. It is predominantly expressed in liver, kidney, lung, skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to down-regulate angiogenesis by blocking VEGF-induced endothelial cell migration. Endostatin may also be involved with down-regulation of angiogenesis after establishment of placental circulation in the pregnant uterus.
Synonym: antiangiogenic agent,COL18A1,collagen alpha-1(XVIII)chain, collagen,type XVIII,Endostatin
- 分子量
- 21.2 kDa
- UniProt
- P39061
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