ERN1 Protein (AA 465-977) (GST tag,His tag)
-
- 抗原 See all ERN1 蛋白
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 465-977
-
宿主
- 人
-
资源
- Baculovirus infected Insect Cells
- 标记
- This ERN1 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human ERN1/IRE1 Protein (aa 465-977, His & GST Tag)(Active)
- 序列
- Pro 465-Leu 977
- 产品特性
- A DNA sequence encoding the human ERN1 isoform 1 (O75460-1) cytoplasmic domain (Pro 465-Leu 977) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 80 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- 1.Kinase activity untested 2. The specific activity was determined to be 5 nmol/min/mg using MBP as substrate
- Top Product
- Discover our top product ERN1 蛋白
-
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 1-70) protein (GST tag)
ERN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 401-500) protein (GST tag)ERN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 19-443) protein (His tag)Crystallography grade ERN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 21-445) protein (His tag)Crystallography grade ERN1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 465-977) protein (His tag)Crystallography grade ERN1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 467-977) protein (His tag)Crystallography grade ERN1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 19-977) protein (rho-1D4 tag)Crystallography grade ERN1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) (AA 21-977) protein (rho-1D4 tag)Crystallography grade ERN1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) protein (Myc-DYKDDDDK Tag)ERN1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 限制
- 仅限研究用
-
- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
- 抗原
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
- 别名
- ERN1/IRE1 (ERN1 产品)
- 别名
- IRE1 Protein, IRE1P Protein, IRE1a Protein, hIRE1p Protein, 9030414B18Rik Protein, AI225830 Protein, C85377 Protein, Ire1a Protein, Ire1alpha Protein, Ire1p Protein, RGD1559716 Protein, Ern1 Protein, Ire1 Protein, Ire1b Protein, sb:eu1005 Protein, zgc:109932 Protein, endoplasmic reticulum to nucleus signaling 1 Protein, endoplasmic reticulum to nucleus signaling 2 Protein, endoplasmic reticulum (ER) to nucleus signalling 1 Protein, serine/threonine-protein kinase/endoribonuclease IRE1 Protein, endoplasmic reticulum (ER) to nucleus signalling 2 Protein, ERN1 Protein, ERN2 Protein, Ern1 Protein, LOC524719 Protein, Ern2 Protein, ern1 Protein
- 背景
-
Background: The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Synonym: hIRE1p,IRE1,IRE1a,IRE1P
- 分子量
- 86 kDa
- 途径
- ER-Nucleus Signaling, Unfolded Protein Response
-
