CRTAM Protein (His tag)
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- 抗原 See all CRTAM 蛋白
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 人细胞
- 标记
- This CRTAM protein is labelled with His tag.
- 原理
- Recombinant Human CRTAM /CD355 Protein (His Tag)(Active)
- 序列
- Ser18-Ser286
- 产品特性
- Recombinant Human Cytotoxic and Regulatory T-Cell Molecule is produced by our Mammalian expression system and the target gene encoding Ser18-Ser286 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Mouse CADM1-Fc(Cat: PKSM041213) at 2μg/ml(100 μl/well) can bind Human CRTAM-His. The ED50 of Human CRTAM-His is 4.905 ug/ml .
- Top Product
- Discover our top product CRTAM 蛋白
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Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (Fc Tag)
CRTAM 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-289) protein (His tag)CRTAM 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-287) protein (His tag)CRTAM 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 1-393) protein (GST tag)CRTAM 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-285) protein (His tag)Crystallography grade CRTAM 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 18-393) protein (rho-1D4 tag)Crystallography grade CRTAM 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cytotoxic and Regulatory T Cell Molecule (CRTAM) (AA 17-389) protein (rho-1D4 tag)Crystallography grade CRTAM 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CRTAM (Cytotoxic and Regulatory T Cell Molecule (CRTAM))
- 别名
- CRTAM /CD355 (CRTAM 产品)
- 别名
- TAD Protein, cTADS Protein, MGC82176 Protein, CRTAM Protein, CD355 Protein, cytotoxic and regulatory T-cell molecule Protein, cytotoxic and regulatory T-cell molecule L homeolog Protein, cytotoxic and regulatory T cell molecule Protein, CRTAM Protein, crtam.L Protein, Crtam Protein
- 背景
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Background: Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNγ or IL-22 production.
Synonym: Cytotoxic and Regulatory T-Cell Molecule, Class-I MHC-Restricted T-Cell-Associated Molecule, CD355, CRTAM
- 分子量
- 31.0 kDa
- UniProt
- O95727
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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