Cyclin H Protein (CCNH) (His tag)
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- 抗原 See all Cyclin H (CCNH) 蛋白
- Cyclin H (CCNH)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Cyclin H protein is labelled with His tag.
- 原理
- Recombinant Human Cyclin-H/CCNH Protein (His Tag)
- 序列
- Met 1-Leu323
- 产品特性
- Recombinant Human Cyclin-H is produced by our E.coli expression system and the target gene encoding Met1-Leu323 is expressed with a 6His tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CCNH 蛋白
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Cyclin H (CCNH) (AA 1-323) protein (GST tag)
CCNH 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Cyclin H (CCNH) (AA 1-110) protein (GST tag)CCNH 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Cyclin H (CCNH) (AA 1-323) protein (Strep Tag)Crystallography grade CCNH 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Cyclin H (CCNH) (AA 1-323) protein (Strep Tag)Crystallography grade CCNH 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Cyclin H (CCNH) protein (Myc-DYKDDDDK Tag)CCNH 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM Tris,100 mM NaCl,2 mM EDTA,2 mM DTT,30 % Glycerol, pH 8.5.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- Cyclin H (CCNH)
- 别名
- Cyclin-H/CCNH (CCNH 产品)
- 别名
- zgc:114132 Protein, cak Protein, p34 Protein, p37 Protein, Cych Protein, ACYPI004637 Protein, ccnh Protein, Cyclin-H Protein, 142767_at Protein, CG7405 Protein, Dmel\\CG7405 Protein, CAK Protein, 6330408H09Rik Protein, AI661354 Protein, AV102684 Protein, AW538719 Protein, ccnh-A Protein, cyclin H Protein, cyclin-H Protein, Cyclin H Protein, CYclin H Protein, cyclin H L homeolog Protein, CCNH Protein, ccnh Protein, LOC5577539 Protein, Cych Protein, CycH Protein, cyh-1 Protein, Ccnh Protein, ccnh.L Protein
- 背景
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Background: Human CCNH, also known as Cyclin-H,MO15-associated protein,p34 and p37, is a protein which belongs to the highly conserved cyclin family. Cyclin family members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1.CCNH regulates CDK7 which is the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. CCNH is also involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Synonym: Cyclin-H,CCNH,MO15-associated protein,p34,p37
- 分子量
- 39.8 kDa
- UniProt
- P51946
- 途径
- Cell Division Cycle, Mitotic G1-G1/S Phases, M Phase
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