Cyclin D2 Protein (CCND2) (His tag)
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- 抗原 See all Cyclin D2 (CCND2) 蛋白
- Cyclin D2 (CCND2)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Cyclin D2 protein is labelled with His tag.
- 原理
- Recombinant Human Cyclin-D2/CCND2 Protein (His Tag)
- 序列
- Met 1-Leu289
- 产品特性
- Recombinant Human Cyclin-D2 is produced by our E.coli expression system and the target gene encoding Met1-Leu289 is expressed with a 6His tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CCND2 蛋白
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Cyclin D2 (CCND2) (AA 1-289) protein (GST tag)
CCND2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cyclin D2 (CCND2) (AA 190-289) protein (GST tag)CCND2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cyclin D2 (CCND2) (AA 1-289) protein (Strep Tag)Crystallography grade CCND2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Cyclin D2 (CCND2) (AA 1-289) protein (Strep Tag)Crystallography grade CCND2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Cyclin D2 (CCND2) proteinCCND2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP
Cyclin D2 (CCND2) protein (Myc-DYKDDDDK Tag)CCND2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl,5 mM DTT, pH 7.5.
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- Cyclin D2 (CCND2)
- 别名
- Cyclin-D2/CCND2 (CCND2 产品)
- 别名
- si:ch211-240j22.2 Protein, ccnd2 Protein, CCND2 Protein, kiak0002 Protein, zgc:162280 Protein, LOC100224096 Protein, KIAK0002 Protein, BF642806 Protein, C86853 Protein, Vin-1 Protein, Vin1 Protein, cD2 Protein, 2600016F06Rik Protein, AI256817 Protein, cyclin D2, b Protein, cyclin D2 S homeolog Protein, cyclin D2 Protein, G1/S-specific cyclin-D2 Protein, cyclin D2, a Protein, cyclin D2 L homeolog Protein, ccnd2b Protein, ccnd2.S Protein, CCND2 Protein, ccnd2 Protein, ccnd2a Protein, Ccnd2 Protein, ccnd2.L Protein
- 背景
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Background: CCND2,also known as G1/S-specific cyclin-D2,is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such as phosphorylating and inhibiting members of the retinoblastoma (RB) protein family including RB1 and regulating the cell-cycle during G1/S transition. It is also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Synonym: G1/S-specific cyclin-D2,CCND2,
- 分子量
- 35.4 kDa
- UniProt
- P30279
- 途径
- Cell Division Cycle, Mitotic G1-G1/S Phases
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