Coronin 6 Protein (CORO6) (His tag)
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- 抗原 See all Coronin 6 (CORO6) products
- Coronin 6 (CORO6)
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This Coronin 6 protein is labelled with His tag.
- 原理
- Recombinant Human Coronin-6/CORO6 Protein (His Tag)
- 序列
- Met 1-Asp237
- 产品特性
- Recombinant Human Coronin-6 is produced by our E.coli expression system and the target gene encoding Met1-Asp237 is expressed with a 6His tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Coronin 6 (CORO6) (AA 1-237) protein (GST tag)
CORO6 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Coronin 6 (CORO6) protein (Myc-DYKDDDDK Tag)CORO6 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Coronin 6 (CORO6)
- 别名
- Coronin-6/CORO6 (CORO6 产品)
- 别名
- coronin 6 Protein, CORO6 Protein, Coro6 Protein
- 背景
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Background: Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is prominently expressed in adult muscle and enriched at the NMJ. Studies with cultured myotubes reveal that Coronin 6 regulates both agrin- and laminin-induced AChR clustering and is important for anchoring AChRs onto the actin cytoskeleton. Also, both the C-terminal region and a conserved Arg29 residue at the N terminus of Coronin 6 are essential for its actin-binding activity and stabilization of AChR-cytoskeleton linkage. Importantly, in vivo knockdown of Coronin 6 in mouse skeletal muscle fibers leads to destabilization of AChR clusters, which demonstrates that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the NMJs through modulating the receptor-anchored actin cytoskeleton. The human Coronin 6 has five isoforms produced by alternative splicing, and tissue-specific expression of these isoforms are unclear.
Synonym: Coronin-6, Clipin-E, CORO6
- 分子量
- 28.3 kDa
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