CNTNAP2 Protein (His tag)
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- 抗原 See all CNTNAP2 蛋白
- CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This CNTNAP2 protein is labelled with His tag.
- 原理
- Recombinant Mouse CNTNAP2/CASPR2 Protein (His Tag)(Active)
- 序列
- Met 1-Ser 1262
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse CASPR2 (NP_001004357.2) (Met 1-Ser 1262) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by the ability of the immobilized protein to support the adhesionof C6 Rat brain glial cells. Mouse CASPR2 immobilized (0.8 μg/ml, 100 μl/well) will mediate >30 % C6 cell adhesion.
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Contactin Associated Protein-Like 2 (CNTNAP2) (AA 28-1262) protein (His tag)
Crystallography grade CNTNAP2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, Crys, ELISA
Contactin Associated Protein-Like 2 (CNTNAP2) (AA 28-1262) protein (His tag)Crystallography grade CNTNAP2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, Crys, ELISA
Contactin Associated Protein-Like 2 (CNTNAP2) (AA 28-1331) protein (rho-1D4 tag)Crystallography grade CNTNAP2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, Crys, ELISA
Contactin Associated Protein-Like 2 (CNTNAP2) (AA 28-1332) protein (rho-1D4 tag)Crystallography grade CNTNAP2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, Crys, ELISA
Contactin Associated Protein-Like 2 (CNTNAP2) protein (Myc-DYKDDDDK Tag)CNTNAP2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CNTNAP2 (Contactin Associated Protein-Like 2 (CNTNAP2))
- 别名
- CNTNAP2/CASPR2 (CNTNAP2 产品)
- 别名
- AUTS15 Protein, CASPR2 Protein, CDFE Protein, NRXN4 Protein, PTHSL1 Protein, 5430425M22Rik Protein, Caspr2 Protein, mKIAA0868 Protein, CASPR Protein, MGC145769 Protein, MGC147944 Protein, MGC147981 Protein, contactin associated protein like 2 Protein, contactin associated protein-like 2 Protein, contactin associated protein like 2b Protein, CNTNAP2 Protein, Cntnap2 Protein, cntnap2b Protein, cntnap2 Protein
- 背景
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Background: CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This protein encoding gene is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. CNTNAP2/CASPR2 may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2/CASPR2 Seems to demarcate the juxtaparanodal region of the axo-glial junction.
Synonym: 5430425M22Rik,Caspr2,mKIAA0868
- 分子量
- 139 kDa
- NCBI登录号
- NP_001004357
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