CTHRC1 Protein (His tag)
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- 抗原 See all CTHRC1 蛋白
- CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))
- 蛋白类型
- Recombinant
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宿主
- 大鼠
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资源
- HEK-293 Cells
- 标记
- This CTHRC1 protein is labelled with His tag.
- 原理
- Recombinant Rat CTHRC1 Protein (His Tag)
- 序列
- Met1-Lys230
- 产品特性
- A DNA sequence encoding the rat Cthrc1 (NP_001258229.1) (Met1-Lys230) was expressed with a polyhistidine tag at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg protein as determined by the LAL method.
- Top Product
- Discover our top product CTHRC1 蛋白
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Collagen Triple Helix Repeat Containing 1 (CTHRC1) (AA 31-136) protein (His-IF2DI Tag)
CTHRC1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Collagen Triple Helix Repeat Containing 1 (CTHRC1) (AA 1-243) protein (GST tag)CTHRC1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Collagen Triple Helix Repeat Containing 1 (CTHRC1) (AA 32-141) protein (GST tag)CTHRC1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Collagen Triple Helix Repeat Containing 1 (CTHRC1) (AA 33-245) protein (His tag)Crystallography grade CTHRC1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))
- 别名
- CTHRC1 (CTHRC1 产品)
- 别名
- CTHRC1 Protein, cthrc1 Protein, zgc:101075 Protein, 1110014B07Rik Protein, collagen triple helix repeat containing 1 Protein, collagen triple helix repeat containing 1a Protein, CTHRC1 Protein, cthrc1 Protein, cthrc1a Protein, Cthrc1 Protein
- 背景
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Background: Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.
Synonym: CTHRC1
- 分子量
- 22.8 kDa
- NCBI登录号
- NP_001258229
- 途径
- Tube Formation
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