CHEK2 Protein (His-GST)
Our Local Distributor
北京 101111
Quick Overview for CHEK2 Protein (His-GST) (ABIN7320011)
抗原
See all CHEK2 蛋白蛋白类型
生物活性
宿主
资源
纯度
-
-
标记
- This CHEK2 protein is labelled with His-GST.
-
原理
- Recombinant Mouse CHK2/CHEK2 Protein (His & GST Tag)
-
序列
- Mey 1-Leu 546
-
产品特性
- A DNA sequence encoding the mouse CHEK2 (Q9Z265) (Mey 1-Leu 546) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
-
过滤
- 0.2 μm filtered
-
内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
-
Biological Activity Comment
- Kinase activity untested
-
-
想要此Protein的其他选项吗？
!探索我们的预定义定制蛋白和定制蛋白服务！Product表达系统ConjugateOrigin价格从表达系统 Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin Mouse价格从 145,985.55 ¥您的项目需要进一步定制吗？联系我们，了解我们的定制蛋白解决方案
-
Checkpoint Kinase 2 (CHEK2) (AA 1-543) protein (GST tag)
CHEK2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Checkpoint Kinase 2 (CHEK2) protein (GST tag)CHEK2 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Checkpoint Kinase 2 (CHEK2) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)CHEK2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, PI, STD Active
-
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 8.0
-
储存条件
- -20 °C
-
储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
有效期
- 6 months
-
-
- CHEK2 (Checkpoint Kinase 2 (CHEK2))
-
别名
- CHK2/CHEK2
-
背景
- CHK2,Cds1,HUCDS1,Rad53,In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded CHEK2 protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in CHEK2s gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.
-
分子量
-
Calculated MW: 89.0 kDa
Observed MW: 90 kDa
-
UniProt
- Q9Z265
-
途径
- p53 Pathway, Apoptosis, Cell Division Cycle
抗原
-
