CD200R1L Protein (His tag)
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- 抗原 See all CD200R1L 蛋白
- CD200R1L (CD200 Receptor 1-Like (CD200R1L))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CD200R1L protein is labelled with His tag.
- 原理
- Recombinant Human CD200R1L/CD200R2/CD200RLa Protein (His Tag)
- 序列
- Met 1-Leu239
- 产品特性
- A DNA sequence encoding the human CD200R1L (AAT00538.1) extracellular domain (Met1-Leu239) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CD200R1L 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CD200R1L (CD200 Receptor 1-Like (CD200R1L))
- 别名
- CD200R1L/CD200R2/CD200RLa (CD200R1L 产品)
- 别名
- CD200R2 Protein, CD200RLa Protein, AY230198 Protein, Cd200r1l Protein, CD200 receptor 1 like Protein, Cd200 receptor 2 Protein, CD200R1L Protein, Cd200r2 Protein
- 背景
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Background: Cell surface glycoprotein CD200 receptor 2, also known as Cell surface glycoprotein CD200 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD200 receptor-like 2, CD200Rla, CD200R1L and CD200R2, is a single-pass type I membrane protein which belongs to the CD200R family. CD200R1L / CD200R2. It contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. CD200 is a transmembrane protein delivering immunoregulatory signals after engagement of CD200R. A family of CD200Rs exist ( CD200R1, CD200R2, CD200R3, CD200R4 ) with different tissue expression and functional activity. In the presence of anti-CD200R2 / CD200R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD200 and one of its receptors, CD200R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3(+) regulatory T cells. Unlike anti-CD200R1, anti-CD200R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg.
Synonym: CD200R2;CD200RLa
- 分子量
- 25.2 kDa
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