Cathepsin Z Protein (CTSZ) (His tag)
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- 抗原 See all Cathepsin Z (CTSZ) 蛋白
- Cathepsin Z (CTSZ)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Cathepsin Z protein is labelled with His tag.
- 原理
- Recombinant Human Cathepsin Z Protein (His Tag)(Active)
- 序列
- Met 1-Val 303
- 产品特性
- A DNA sequence encoding the human CTSZ (Q9UBR2) (Met 1-Val 303) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp)-OH,R&D Systems, Catalog # ES005.The specific activity is >800 pmoles/min/μg.
- Top Product
- Discover our top product CTSZ 蛋白
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Cathepsin Z (CTSZ) (AA 1-303) protein (GST tag)
CTSZ 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin Z (CTSZ) (Active) protein (His tag)CTSZ 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Cathepsin Z (CTSZ) (AA 62-303) protein (His tag)Crystallography grade CTSZ 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cathepsin Z (CTSZ) (AA 64-306) protein (His tag)Crystallography grade CTSZ 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Cathepsin Z (CTSZ)
- 别名
- Cathepsin Z (CTSZ 产品)
- 别名
- wu:fj81f10 Protein, zgc:103420 Protein, CTSZ Protein, CTSX Protein, AI787083 Protein, AU019819 Protein, D2Wsu143e Protein, CATX Protein, CathePsin Z Protein, cathepsin Z Protein, cathepsin Z S homeolog Protein, papain family cysteine protease Protein, cpz-1 Protein, cpz-2 Protein, CTSZ Protein, ctsz Protein, ctsz.S Protein, TTHERM_00102779 Protein, NAEGRDRAFT_78125 Protein, Ctsz Protein
- 背景
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Background: Cathepsin Z (CTSZ); also known as Cathepsin X or CATX; belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus; and in contrast to cathepsin B; it does not act as an endopeptidase. It is restricted to the cells of theimmune system; predominantly monocytes; macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues; suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells; a process; which is crucial in the initiation of adaptive immunity. Furthermore; higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa; especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources; suggesting that this enzyme may participate in tumor progression.
Synonym: Cathepsin Z; Cathepsin P; Cathepsin X; CTSZ
- 分子量
- 33 kDa
- UniProt
- Q9UBR2
- 途径
- Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones
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