Cathepsin L2 Protein (CTSL2) (His tag)
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- 抗原 See all Cathepsin L2 (CTSL2) 蛋白
- Cathepsin L2 (CTSL2)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Cathepsin L2 protein is labelled with His tag.
- 原理
- Recombinant Human Cathepsin L2/CTSL2 Protein (His Tag)(Active)
- 序列
- Met 1-Val 334
- 产品特性
- A DNA sequence encoding the full length of human cathepsin L2 (NP_001324.2) (Met 1-Val 334) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC, (R&D Systems, Catalog # ES008). The specific activity is >1000 pmoles/min/μg.
- Top Product
- Discover our top product CTSL2 蛋白
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Cathepsin L2 (CTSL2) (AA 18-334) protein (His-IF2DI Tag)
CTSL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Cathepsin L2 (CTSL2) (AA 1-334) protein (GST tag)CTSL2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin L2 (CTSL2) (AA 114-334) protein (His tag)Crystallography grade CTSL2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cathepsin L2 (CTSL2) proteinCTSL2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Cathepsin L2 (CTSL2) (AA 64-334) (Active) protein (His tag)CTSL2 宿主: 人 宿主: 大肠杆菌（E. Coli） > 95 % AcA, CC Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Cathepsin L2 (CTSL2)
- 别名
- Cathepsin L2/CTSL2 (CTSL2 产品)
- 别名
- CATL2 Protein, CTSL2 Protein, CTSU Protein, CTSL Protein, CTSL1 Protein, ctsl2 Protein, LOC100232421 Protein, cathepsin V Protein, cathepsin V L homeolog Protein, cathepsin L Protein, CTSV Protein, ctsv.L Protein, ctsv Protein, CTSL Protein, Ctsv Protein
- 背景
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Background: Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin. It is a lysosomal cysteine proteinase that may play an important role in corneal physiology. It has about 75 % protein sequence identity to murine cathepsin L. The fold of this enzyme is similar to the fold adopted by other members of the papain superfamily of cysteine proteases. Cathepsin V has been recently described as highly homologous to Cathepsin L and exclusively expressed in human thymus and testis. Cathepsin V is the dominant cysteine protease in cortical human thymic epithelial cells, while Cathepsin L and Cathepsin S seem to be restricted to dendritic and macrophage-like cells. Active Cathepsin V in thymic lysosomal preparations was demonstrated by active-site labeling. Recombinant Cathepsin V was capable of converting Ii into CLIP efficiently, suggesting that it is the protease that controls the generation of alphabeta-CLIP complexes in the human thymus. Cathepsin V is the third elastolytic cysteine protease which exhibits the most potent elastase activity yet described among human proteases and that it is present in atherosclerotic plaque specimens. Cathepsin L2 may play a specialized role in the thymus and testis. Expression analysis of cathepsin L2 in human tumors revealed a widespread expression in colorectal and breast carcinomas but not in normal colon or mammary gland or in peritumoral tissues. Cathepsin L2 was also expressed by colorectal and breast cancer cell lines as well as by some tumors of diverse origin, including ovarian and renal carcinomas.
Synonym: Cathepsin L2, Cathepsin U, Cathepsin V, CTSL2, CATL2, CTSU, CTSV
- 分子量
- 37.1 kDa
- NCBI登录号
- NP_001324
- 途径
- Toll-Like Receptors Cascades
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