Cathepsin L Protein (AA 1-334) (His tag)
-
- 抗原 See all Cathepsin L (CTSL1) 蛋白
- Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-334
-
宿主
- 小鼠
-
资源
- HEK-293 Cells
- 标记
- This Cathepsin L protein is labelled with His tag.
- 原理
- Recombinant Mouse Cathepsin L/CTSL Protein (aa 1-334, His Tag)
- 序列
- Met 1-Asn 334
- 产品特性
- A DNA sequence encoding the mouse CTSL (P06797) (Met 1-Asn 334) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product CTSL1 蛋白
-
Cathepsin L1 (CTSL1) (AA 18-333) protein (His tag)
CTSL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Cathepsin L1 (CTSL1) (AA 1-333) protein (GST tag)CTSL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin L1 (CTSL1) (AA 18-333) protein (GST tag)CTSL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin L1 (CTSL1) (AA 18-334) protein (His tag)CTSL1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Cathepsin L1 (CTSL1) (AA 292-333) protein (His tag)Crystallography grade CTSL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cathepsin L1 (CTSL1) (AA 291-334) protein (His tag)Crystallography grade CTSL1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cathepsin L1 (CTSL1) (AA 114-288) protein (His tag)Crystallography grade CTSL1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cathepsin L1 (CTSL1) (AA 114-288) protein (His tag)Crystallography grade CTSL1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))
- 别名
- Cathepsin L/CTSL (CTSL1 产品)
- 别名
- CATL Protein, CTSL1 Protein, MEP Protein, 1190035F06Rik Protein, Ctsl1 Protein, fs Protein, nkt Protein, CATHL Protein, CatL Protein, Ctsl Protein, CTSL Protein, mep Protein, catl Protein, ctsl Protein, cpl-1 Protein, MGC80629 Protein, MGC107932 Protein, LOC663234 Protein, 26-29-p Protein, Cp1 Protein, si:dkey-121a11.6 Protein, CTSV Protein, catL Protein, cb15 Protein, ctsl1b Protein, hgg1 Protein, wu:fb30g09 Protein, zgc:92089 Protein, cathepsin L Protein, cathepsin V Protein, cathepsin L L homeolog Protein, cathepsin L1 Protein, Cathepsin L1 Protein, Cathepsin L Protein, testin gene Protein, cathepsin 12 Protein, cathepsin Lb Protein, cathepsin L.1 Protein, CTSL Protein, Ctsl Protein, CTSV Protein, ctsl.L Protein, ctsl Protein, LOC100008830 Protein, catl1 Protein, 26-29-p Protein, catl Protein, Tsp_11596 Protein, Testin Protein, cts12 Protein, LOC102156614 Protein, ctslb Protein, ctsl.1 Protein
- 背景
-
Background: Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. It is secreted by liver flukes at all stages of their development in the mammalian host, are believed to play important roles in facilitating parasite migration (tissue degradation), feeding and immuno-evasion. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. The enzyme takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin and native collagen and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Recently, Cathepsin L has been shown to suppress Th1 immune response in infected laboratory animals making them susceptible to concurrent bacterial infections. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy.
Synonym: Cathepsin L1, Major excreted protein, p39 cysteine proteinase, Ctsl1,1190035F06Rik
- 分子量
- 37.3 kDa
- UniProt
- P06797
- 途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
-
