CTSC Protein (His tag)
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- 抗原 See all CTSC 蛋白
- CTSC (Cathepsin C (CTSC))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CTSC protein is labelled with His tag.
- 原理
- Recombinant Human Cathepsin C/CTSC/DPPI Protein (His Tag)(Active)
- 序列
- Met 1-Leu 463
- 产品特性
- A DNA sequence encoding the pro form of human cathepsin C (NP_001805.3) (Met 1-Leu 463) was expressed with a polyhistidine tag at the C-terminus.
- 纯度
- > 92 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GRAMC). The specific activity is >200 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by Cathepsin L for an activated form)
- Top Product
- Discover our top product CTSC 蛋白
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Cathepsin C (CTSC) (AA 1-463) protein (GST tag)
CTSC 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin C (CTSC) (AA 395-463) protein (His tag)Crystallography grade CTSC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cathepsin C (CTSC) (AA 25-134) protein (His tag)Crystallography grade CTSC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cathepsin C (CTSC) (AA 25-134) protein (His tag)Crystallography grade CTSC 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cathepsin C (CTSC) (AA 394-462) protein (His tag)Crystallography grade CTSC 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cathepsin C (CTSC) (AA 231-394) protein (His tag)Crystallography grade CTSC 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cathepsin C (CTSC) (AA 231-393) protein (His tag)Crystallography grade CTSC 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CTSC (Cathepsin C (CTSC))
- 别名
- Cathepsin C/CTSC/DPPI (CTSC 产品)
- 别名
- CPPI Protein, DPP-I Protein, DPP1 Protein, DPPI Protein, HMS Protein, JP Protein, JPD Protein, PALS Protein, PDON1 Protein, PLS Protein, MGC69126 Protein, MGC107782 Protein, AI047818 Protein, CATC Protein, cb912 Protein, ik:tdsubc_1h2 Protein, sb:cb146 Protein, wu:fb34g12 Protein, wu:fj58d01 Protein, cathepsin C Protein, cathepsin C L homeolog Protein, cathepsin CPC1 Protein, CTSC Protein, ctsc.L Protein, ctsc Protein, TP03_0357 Protein, CMU_003360 Protein, CPC1 Protein, NAEGRDRAFT_80477 Protein, NAEGRDRAFT_37577 Protein, Ctsc Protein, Smp_183330 Protein
- 背景
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Background: Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPPI/DPP1), activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal dipeptides. This lysosomal exo-cysteine protease belonging to the peptidase C1 family. Active cathepsin C is found in lysosomes as a 200- kDa multimeric enzyme. Subunits constituting this assembly all arise from the proteolytic cleavage of a single precursor giving rise to three peptides: the propeptide, the alpha- and the beta-chains. It is a central coordinator for activation of many serine proteases in immune/inflammatory cells. Defects in the Cathepsin C have been shown to be a cause of Papillon-Lefevre disease, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Cathepsin C plays a key role in the activation of several degradative enzymes linked to tissue destruction in inflammatory diseases. Thus, it is a therapeutic target for the treatment of a number of inflammatory and autoimmune diseases.
Synonym: CPPI,DPP-I,DPP1,DPPI,HMS,JP,JPD,PALS,PDON1,PLS
- 分子量
- 51 kDa
- NCBI登录号
- NP_001805
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