CNDP1 Protein (His tag)
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- 抗原 See all CNDP1 蛋白
- CNDP1 (Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CNDP1 protein is labelled with His tag.
- 原理
- Recombinant Human CNDP1 Protein (His Tag)(Active)
- 序列
- Ser27-His507
- 产品特性
- A DNA sequence encoding the mature form of human CNDP1 (NP_116038.4) (Ser27-His507) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave carnosine (β-Ala-L-His) in a two-step assay.The specific activity is > 250 pmoles/min/μg.
- Top Product
- Discover our top product CNDP1 蛋白
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Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 28-147) protein (His-IF2DI Tag)
CNDP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 1-507) protein (GST tag)CNDP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (Active) protein (His tag)CNDP1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 93 % as determined by SDS-PAGE Active
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 1-492) protein (Strep Tag)Crystallography grade CNDP1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 27-507) protein (His tag)Crystallography grade CNDP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) (AA 1-492) protein (His tag)CNDP1 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 95 % by SDS - PAGE SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CNDP1 (Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1))
- 别名
- CNDP1 (CNDP1 产品)
- 别名
- cn1 Protein, cpgl2 Protein, CNDP1 Protein, CN1 Protein, CPGL2 Protein, HsT2308 Protein, AI746433 Protein, Cn1 Protein, carnosine dipeptidase 1 (metallopeptidase M20 family) L homeolog Protein, carnosine dipeptidase 1 Protein, carnosine dipeptidase 1 (metallopeptidase M20 family) Protein, cndp1.L Protein, CNDP1 Protein, cndp1 Protein, Cndp1 Protein
- 背景
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Background: CNDP1; also known as carnosine dipeptidase 1; glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1); is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region; which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy; for carnosine protection against the adverse effects of high glucose levels on renal cells. In humans; CNDP1 is secreted from the liver into the serum. In other mammals; including rodents; CNDP1 is expressed exclusively within the kidney and lacks a signal peptide. CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine (β-alanyl-L-histidine); and is identified as human carnosinase expressed in the brain. CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans; but not African-Americans. It was identified and confirmed as a risk factor; were cross-sectional and mostly in patients with type 2 diabetes. The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes. In addition; CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.
Synonym: Beta-Ala-His Dipeptidase; CNDP Dipeptidase 1; Carnosine Dipeptidase 1; Glutamate Carboxypeptidase-Like Protein 2; Serum Carnosinase; CNDP1; CN1; CPGL2;HsT2308
- 分子量
- 55.3 kDa
- NCBI登录号
- NP_116038
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