CPB2 Protein (His tag)
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- 抗原 See all CPB2 蛋白
- CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CPB2 protein is labelled with His tag.
- 原理
- Recombinant Human Carboxypeptidase B2/CPB2 Protein (His Tag)
- 序列
- Met 1-Val 423
- 产品特性
- A DNA sequence encoding the human CPB2 (NP_001863.2) extracellular domain (Met 1-Val 423) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CPB2 蛋白
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Carboxypeptidase B2 (Plasma) (CPB2) (AA 1-423) protein (GST tag)
CPB2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Carboxypeptidase B2 (Plasma) (CPB2) (AA 20-129) protein (GST tag)CPB2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Carboxypeptidase B2 (Plasma) (CPB2) protein (His tag)CPB2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE
Carboxypeptidase B2 (Plasma) (CPB2) protein (His tag)CPB2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Carboxypeptidase B2 (Plasma) (CPB2) (AA 115-423) protein (His tag)Crystallography grade CPB2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Carboxypeptidase B2 (Plasma) (CPB2) (AA 114-422) protein (His tag)Crystallography grade CPB2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
- 别名
- Carboxypeptidase B2/CPB2 (CPB2 产品)
- 别名
- CPU Protein, PCPB Protein, TAFI Protein, 1110032P04Rik Protein, 4930405E17Rik Protein, AI255929 Protein, CPR Protein, Cpu Protein, pCPB Protein, zgc:112493 Protein, carboxypeptidase B2 Protein, carboxypeptidase B2 (plasma) Protein, CPB2 Protein, Cpb2 Protein, cpb2 Protein
- 背景
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Background: Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin / thrombomodulin complex. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. CPB2 exhibits carboxypeptidase activity and activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.
Synonym: Carboxypeptidase B2, Carboxypeptidase U, CPU, Plasma Carboxypeptidase B, pCPB, Thrombin-Activable Fibrinolysis Inhibitor, TAFI, CPB2
- 分子量
- 47.4 kDa
- NCBI登录号
- NP_001863
- 途径
- Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis
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