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CAMK1G Protein (GST tag,His tag)

CAMK1G 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 85 % as determined by reducing SDS-PAGE.
产品编号 ABIN7317051
发货至: 中国
  • 抗原 See all CAMK1G 蛋白
    CAMK1G (Calcium/calmodulin-Dependent Protein Kinase IG (CAMK1G))
    蛋白类型
    Recombinant
    宿主
    • 5
    • 1
    • 1
    资源
    • 2
    • 2
    • 1
    • 1
    • 1
    Baculovirus infected Insect Cells
    标记
    This CAMK1G protein is labelled with GST tag,His tag.
    原理
    Recombinant Human CAMK1G/CaMKI gamma Protein (His & GST Tag)
    序列
    Met 1-Met 476
    产品特性
    A DNA sequence encoding the human CAMK1G isoform 1 (Q96NX5-1) (Met 1-Met 476) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
    纯度
    > 85 % as determined by reducing SDS-PAGE.
    内毒素水平
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product CAMK1G 蛋白
  • 限制
    仅限研究用
  • 状态
    Frozen, Liquid
    缓冲液
    Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 20 % glycerol, 0.3 mM DTT
    储存条件
    -20 °C
    储存方法
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • 抗原
    CAMK1G (Calcium/calmodulin-Dependent Protein Kinase IG (CAMK1G))
    别名
    CAMK1G/CaMKI gamma (CAMK1G 产品)
    别名
    camk1g Protein, wu:fk53c02 Protein, zgc:73127 Protein, CAMK1G Protein, Ci-CaM-K Protein, wu:fk61c03 Protein, zgc:73155 Protein, CLICK-III Protein, CaMKIgamma Protein, CLICK3 Protein, CLICKIII Protein, VWS1 Protein, dJ272L16.1 Protein, calcium/calmodulin-dependent protein kinase IGa Protein, calcium/calmodulin-dependent protein kinase IG Protein, calmodulin-dependent protein kinase homologue Protein, calcium/calmodulin dependent protein kinase IG Protein, calcium/calmodulin-dependent protein kinase IGb Protein, calcium/calmodulin-dependent protein kinase I gamma Protein, camk1ga Protein, CAMK1G Protein, cam-k Protein, camk1gb Protein, Camk1g Protein
    背景

    Background: Calmodulin-Dependent Protein Kinase (CaM Kinase) is a kind of protein phosphorylate multiple downstream targets. Concentration of cytosolic calcium functions as a second messenger that mediates a wide range of cellular responses. Calcium binds to calcium binding proteins (calmodulin/CaM) and stimulates the activity of a variety of enzymes, including CaM kinases referred to as CaM-kinases (CaMKs), such as CaMKI, CaMKII, CaMKIV and CaMKK. Calmodulin-dependent protein kinase CL3/CaMKIγ is a memberane-anchored CaMK belonging to the CaM kinase family. Its C-terminal region is uniquely modified by two sequential lipidification steps: prenylation followed by a kinase-activity-regulated palmitoylation. These modifications are essential for CaMKIγ membrane anchoring and targeting into detergent-resistant lipid microdomains in the dendrites. It has been found that CaMKIγ critically contributed to BDNF-stimulated dendritic growth. Raft insertion of CaMKIγ specifically promoted dendritogenesis of cortical neurons by acting upstream of RacGEF STEF and Rac, both present in lipid rafts. Thus, CaMKIγ may represent a key element in the Ca2+-dependent and lipid-raft-delineated switch that turns on extrinsic activity-regulated dendrite formation in developing cortical neurons. 

    Synonym: CLICK3;CLICKIII;dJ272L16.1;RP1-272L16.2;VWS1

    分子量
    81 kDa
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