CAMK1G Protein (GST tag,His tag)
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- 抗原 See all CAMK1G 蛋白
- CAMK1G (Calcium/calmodulin-Dependent Protein Kinase IG (CAMK1G))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This CAMK1G protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human CAMK1G/CaMKI gamma Protein (His & GST Tag)
- 序列
- Met 1-Met 476
- 产品特性
- A DNA sequence encoding the human CAMK1G isoform 1 (Q96NX5-1) (Met 1-Met 476) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CAMK1G 蛋白
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 20 % glycerol, 0.3 mM DTT
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- CAMK1G (Calcium/calmodulin-Dependent Protein Kinase IG (CAMK1G))
- 别名
- CAMK1G/CaMKI gamma (CAMK1G 产品)
- 别名
- camk1g Protein, wu:fk53c02 Protein, zgc:73127 Protein, CAMK1G Protein, Ci-CaM-K Protein, wu:fk61c03 Protein, zgc:73155 Protein, CLICK-III Protein, CaMKIgamma Protein, CLICK3 Protein, CLICKIII Protein, VWS1 Protein, dJ272L16.1 Protein, calcium/calmodulin-dependent protein kinase IGa Protein, calcium/calmodulin-dependent protein kinase IG Protein, calmodulin-dependent protein kinase homologue Protein, calcium/calmodulin dependent protein kinase IG Protein, calcium/calmodulin-dependent protein kinase IGb Protein, calcium/calmodulin-dependent protein kinase I gamma Protein, camk1ga Protein, CAMK1G Protein, cam-k Protein, camk1gb Protein, Camk1g Protein
- 背景
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Background: Calmodulin-Dependent Protein Kinase (CaM Kinase) is a kind of protein phosphorylate multiple downstream targets. Concentration of cytosolic calcium functions as a second messenger that mediates a wide range of cellular responses. Calcium binds to calcium binding proteins (calmodulin/CaM) and stimulates the activity of a variety of enzymes, including CaM kinases referred to as CaM-kinases (CaMKs), such as CaMKI, CaMKII, CaMKIV and CaMKK. Calmodulin-dependent protein kinase CL3/CaMKIγ is a memberane-anchored CaMK belonging to the CaM kinase family. Its C-terminal region is uniquely modified by two sequential lipidification steps: prenylation followed by a kinase-activity-regulated palmitoylation. These modifications are essential for CaMKIγ membrane anchoring and targeting into detergent-resistant lipid microdomains in the dendrites. It has been found that CaMKIγ critically contributed to BDNF-stimulated dendritic growth. Raft insertion of CaMKIγ specifically promoted dendritogenesis of cortical neurons by acting upstream of RacGEF STEF and Rac, both present in lipid rafts. Thus, CaMKIγ may represent a key element in the Ca2+-dependent and lipid-raft-delineated switch that turns on extrinsic activity-regulated dendrite formation in developing cortical neurons.
Synonym: CLICK3;CLICKIII;dJ272L16.1;RP1-272L16.2;VWS1
- 分子量
- 81 kDa
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