CIB2 Protein (His tag)
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- 抗原 See all CIB2 蛋白
- CIB2 (Calcium And Integrin Binding Family Member 2 (CIB2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This CIB2 protein is labelled with His tag.
- 原理
- Recombinant Human CIB2/KIP-2 Protein (His Tag)
- 序列
- Met 1-Ile 187
- 产品特性
- A DNA sequence encoding the mature form of human CIB2 (O75838) (Met 1-Ile 187) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 75 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CIB2 蛋白
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Calcium And Integrin Binding Family Member 2 (CIB2) (AA 1-187) protein (His tag)
CIB2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Calcium And Integrin Binding Family Member 2 (CIB2) (AA 1-99) protein (GST tag)CIB2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 20 % glycerol, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CIB2 (Calcium And Integrin Binding Family Member 2 (CIB2))
- 别名
- CIB2/KIP-2 (CIB2 产品)
- 别名
- DFNB48 Protein, KIP2 Protein, USH1J Protein, 2810434I23Rik Protein, AI449053 Protein, calcium and integrin binding family member 2 Protein, CIB2 Protein, Cib2 Protein
- 背景
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Background: Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function and proper development of hair cells and retinal photoreceptor cells. We also show that CIB2 is a new member of the vertebrate Usher interactome. Variants in CIB2 can underlie either Usher syndrome type I (USH1J) or nonsyndromic hearing impairment (NSHI) (DFNB48). CIB2 is widely expressed in various human and animal tissues, mainly in skeletal muscle, nervous tissue, inner ear, and retina. The CIB2 protein is responsible for maintaining Ca(2+) homeostasis in cells and interacting with integrins-transmembrane receptors essential for cell adhesion, migration, and activation of signaling pathways. Calcium signaling pathway is crucial for signal transduction in the inner ear, and integrins regulate hair cell differentiation and maturation of the stereocilia.
Synonym: DFNB48,KIP2,USH1J
- 分子量
- 23.1 kDa
- UniProt
- O75838
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