CLEC7A 蛋白
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- 抗原 See all CLEC7A 蛋白
- CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Recombinant Human Dectin-1/CLEC7A Protein
- 序列
- Thr66-Met201
- 产品特性
- A DNA sequence encoding the extracellular domain of the human Dectin1 (NP_072092.2) (Thr66-Met201) was expressed.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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- Discover our top product CLEC7A 蛋白
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C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 71-244) protein (Fc Tag)
CLEC7A 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 66-201) protein (Fc Tag)CLEC7A 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 1-77) protein (GST tag)CLEC7A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
C-Type Lectin Domain Family 7, Member A (CLEC7A) protein (His tag)CLEC7A 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 1-247) protein (Strep Tag)Crystallography grade CLEC7A 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 1-244) protein (Strep Tag)Crystallography grade CLEC7A 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 66-247) protein (His tag)Crystallography grade CLEC7A 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
C-Type Lectin Domain Family 7, Member A (CLEC7A) (AA 71-244) protein (His tag)Crystallography grade CLEC7A 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))
- 别名
- Dectin-1/CLEC7A (CLEC7A 产品)
- 别名
- CLEC7A Protein, BGR Protein, Clecsf12 Protein, beta-GR Protein, CANDF4 Protein, CLECSF12 Protein, DECTIN1 Protein, Clec7b Protein, RGD1565140 Protein, C-type lectin domain containing 7A Protein, C-type lectin domain family 7, member a Protein, CLEC7A Protein, Clec7a Protein
- 背景
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Background: Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.
Synonym: Beta-glucan receptor, BGR, CD369, CLEC7A, CLECSF12, CLECSF12DC-associated C-type lectin 1,Dectin1, Dectin-1, DECTIN1CANDF4,CANDF4,DECTIN1
- 分子量
- 15.5 kDa
- NCBI登录号
- NP_072092
- 途径
- Activation of Innate immune Response
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