C-Type Lectin Domain Family 1, Member B (CLEC1B) (Active) protein (His tag)
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- 抗原 See all C-Type Lectin Domain Family 1, Member B (CLEC1B) 蛋白
- C-Type Lectin Domain Family 1, Member B (CLEC1B)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- His tag
- 原理
- Recombinant Human CLEC1B/CLEC2 Protein (His Tag)(Active)
- 序列
- Gln 58-Pro 229
- 产品特性
- A DNA sequence encoding the human CLEC1B (NP_057593.3) extracellular domain (Gln 58-Pro 229) with a N-terminal polyhistidine tag was expressed.
- 纯度
- > 76 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized human Podoplanin at 10 μg/mL (100 μl/well) can bind biotinylated human CLEC1B-His, The EC50 of biotinylated human CLEC1B-His is 0.71 μg/mL.
- Top Product
- Discover our top product CLEC1B 蛋白
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C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 1-196) protein (GST tag)
CLEC1B 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 128-229) protein (GST tag)CLEC1B 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 1-229) protein (Strep Tag)Crystallography grade CLEC1B 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 1-229) protein (Strep Tag)Crystallography grade CLEC1B 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 55-229) protein (His tag)Crystallography grade CLEC1B 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
C-Type Lectin Domain Family 1, Member B (CLEC1B) (AA 53-229) protein (His tag)Crystallography grade CLEC1B 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- C-Type Lectin Domain Family 1, Member B (CLEC1B)
- 别名
- CLEC1B/CLEC2 (CLEC1B 产品)
- 别名
- 1810061I13Rik Protein, CLEC2 Protein, CLEC2B Protein, PRO1384 Protein, QDED721 Protein, Clec-2 Protein, Clec2 Protein, CLEC1B Protein, RGD1563517 Protein, CLEC9A Protein, C-type lectin domain family 1 member B Protein, C-type lectin domain family 1, member b Protein, C-type lectin domain family 1, member B Protein, CLEC1B Protein, Clec1b Protein
- 物质类
- Viral Protein
- 背景
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Background: CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
Synonym: 1810061I13Rik,CLEC2,CLEC2B,PRO1384,QDED721
- 分子量
- 22.7 kDa
- NCBI登录号
- NP_057593
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