BACE2 Protein (His tag)
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- 抗原 See all BACE2 蛋白
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This BACE2 protein is labelled with His tag.
- 原理
- Recombinant Mouse BACE2/Beta secretase 2 Protein (His Tag)(Active)
- 序列
- Met1-Pro462
- 产品特性
- A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 .The specific activity is >50 pmoles/min/μg.
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- Discover our top product BACE2 蛋白
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beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 295-419) protein (His-IF2DI Tag)
BACE2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 306-395) protein (GST tag)BACE2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 21-473) protein (His tag)Crystallography grade BACE2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 20-469) protein (His tag)Crystallography grade BACE2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 63-518) protein (rho-1D4 tag)Crystallography grade BACE2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
beta-Site APP-Cleaving Enzyme 2 (BACE2) (AA 63-514) protein (rho-1D4 tag)Crystallography grade BACE2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
beta-Site APP-Cleaving Enzyme 2 (BACE2) proteinBACE2 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- 别名
- BACE2/Beta secretase 2 (BACE2 产品)
- 别名
- AEPLC Protein, ALP56 Protein, ASP1 Protein, ASP21 Protein, BAE2 Protein, CEAP1 Protein, DRAP Protein, 1110059C24Rik Protein, AI850424 Protein, ARP1 Protein, CDA13 Protein, beta-site APP-cleaving enzyme 2 Protein, BACE2 Protein, Bace2 Protein
- 背景
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Background: BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
Synonym: 1110059C24Rik;AEPLC;AI850424;ALP56;ARP1;ASP21;BAE2;CDA13;CEAP1;DRAP
- 分子量
- 49.2 kDa
- UniProt
- Q9JL18
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