ABCB5 Protein (TRX tag)
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- 抗原 See all ABCB5 蛋白
- ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This ABCB5 protein is labelled with TRX tag.
- 原理
- Recombinant Human ABCB5 Protein (Trx Tag)
- 序列
- Ile141-Val247
- 产品特性
- Recombinant Human ATP-binding cassette sub-family B member 5 is produced by our E.coli expression system and the target gene encoding Ile141-Val247 is expressed with a Trx tag at the N-terminus.
- 纯度
- > 85 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ABCB5 蛋白
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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) (AA 141-247) protein (His tag)
ABCB5 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) (AA 1-1257) protein (Strep Tag)Crystallography grade ABCB5 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5) (AA 1-1255) protein (Strep Tag)Crystallography grade ABCB5 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))
- 别名
- ABCB5 (ABCB5 产品)
- 别名
- ABCB5alpha Protein, ABCB5beta Protein, EST422562 Protein, 9230106F14Rik Protein, RGD1566342 Protein, ABCB5 Protein, mdr1 Protein, im:7158730 Protein, wu:fc18f02 Protein, wu:fi81f06 Protein, ATP binding cassette subfamily B member 5 Protein, ATP-binding cassette, sub-family B (MDR/TAP), member 5 Protein, ATP-binding cassette sub-family B member 5 Protein, ABCB5 Protein, Abcb5 Protein, abcb5 Protein, TGME49_249820 Protein, PAAG_04387 Protein, VDBG_00160 Protein, VDBG_02292 Protein
- 背景
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Background: ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.
Synonym: ATP-binding cassette sub-family B member 5, P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5,
- 分子量
- 29.4 kDa
- UniProt
- Q2M3G0
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