ATL1 Protein (GST tag)
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- 抗原 See all ATL1 蛋白
- ATL1 (Atlastin GTPase 1 (ATL1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This ATL1 protein is labelled with GST tag.
- 原理
- Recombinant Human ATL1/SPG3A/Atlastin-1 Protein (GST Tag)
- 序列
- Met 1-Thr 447
- 产品特性
- A DNA sequence encoding the human SPG3A (NP_056999.2) (Met 1-Thr 447) was fused with the GST tag at the N-terminus.
- 纯度
- > 80 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ATL1 蛋白
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Atlastin GTPase 1 (ATL1) (AA 1-100) protein (GST tag)
ATL1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Atlastin GTPase 1 (ATL1) (AA 1-558) protein (Strep Tag)Crystallography grade ATL1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Atlastin GTPase 1 (ATL1) (AA 1-558) protein (Strep Tag)Crystallography grade ATL1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Atlastin GTPase 1 (ATL1) (AA 1-449) protein (His tag)Crystallography grade ATL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Atlastin GTPase 1 (ATL1) (AA 1-449) protein (His tag)Crystallography grade ATL1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Atlastin GTPase 1 (ATL1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)ATL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM EDTA, 0.5 mM GSH, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ATL1 (Atlastin GTPase 1 (ATL1))
- 别名
- ATL1/SPG3A/Atlastin-1 (ATL1 产品)
- 别名
- ATL1 Protein, SPG3A Protein, fj46c01 Protein, wu:fj46c01 Protein, spg3a Protein, MGC146251 Protein, AD-FSP Protein, FSP1 Protein, GBP3 Protein, HSN1D Protein, SPG3 Protein, atlastin1 Protein, 4930435M24Rik Protein, Adfsp Protein, Fsp1 Protein, Spg3 Protein, Spg3a Protein, atlastin Protein, Atlastin-1 Protein, atlastin GTPase 1 Protein, ATL1 Protein, atl1 Protein, Atl1 Protein
- 背景
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Background: Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to the GBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 50-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. ATL1 / SPG3A is also expressed in upper and lower motor neurons (at protein level). A distinguishing feature of ATL1 / SPG3A is its frequent early onset, raising the possibility that developmental abnormalities may be involved in its pathogenesis. Missense SPG3A mutant atlastin-1 proteins have impaired GTPase activity and may act in a dominant-negative, loss-of-function manner by forming mixed oligomers with wild-type atlastin-1. Defects in ATL1 / SPG3A are the cause of spastic paraplegia autosomal dominant type 3 (SPG3), also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
Synonym: AD-FSP;atlastin1;FSP1;GBP3;HSN1D;SPG3;SPG3A
- 分子量
- 77 kDa
- NCBI登录号
- NP_056999
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