GRK2 Protein (GST tag,His tag)
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- 抗原 See all GRK2 (ADRBK1) 蛋白
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This GRK2 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human GRK2/ADRBK1 Protein (His & GST Tag)
- 序列
- Met 1-Leu 689
- 产品特性
- A DNA sequence encoding the human ADRBK1 (NP_001610.2) (Met 1-Leu 689) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ADRBK1 蛋白
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Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 1-689) (Active) protein (GST tag)
ADRBK1 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 1-689) protein (GST tag)ADRBK1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 1-689) protein (Strep Tag)Crystallography grade ADRBK1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 1-689) protein (Strep Tag)Crystallography grade ADRBK1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (AA 2-634), (partial) protein (His tag)ADRBK1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) protein (Myc-DYKDDDDK Tag)ADRBK1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 500 mM NaCl, 0.5 mM GSH, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
- 别名
- GRK2/ADRBK1 (ADRBK1 产品)
- 别名
- Adrbk-1 Protein, Bark-1 Protein, GRK2 Protein, betaARK1 Protein, BARK1 Protein, BETA-ARK1 Protein, GRK-2 Protein, Grk2 Protein, beta-adrenergic receptor kinase 1 Protein, G protein-coupled receptor kinase 2 Protein, Tsp_00497 Protein, grk2 Protein, Grk2 Protein, GRK2 Protein
- 背景
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Background: G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been reported to interact with a variety of signal transduction proteins related to cell migration such as MEK, Akt, PI3Kgamma or GIT. Interestingly, the levels of expression and activity of this kinase are altered in a number of inflammatory disorders (as rheumatoid arthritis or multiple sclerosis), thus suggesting that GRK2 may play an important role in the onset or development of these pathologies. The important physiological function of GRK2 as a modulator of the efficacy of GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors. Besides its canonical role in the modulation of the signalling mediated by many G protein-coupled receptors (GPCR), this protein can display a very complex network of functional interactions with a variety of signal transduction partners, in a stimulus, cell type, or context-specific way.
Synonym: BARK1,BETA-ARK1,GRK2
- 分子量
- 107 kDa
- NCBI登录号
- NP_001610
- 途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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