ACVR1 Protein (His tag,Fc Tag)
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- 抗原 See all ACVR1 (ACRV1) 蛋白
- ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This ACVR1 protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Mouse ALK-2/ACVR1 Protein (His & Fc Tag)(Active)
- 序列
- Met 1-Glu 123
- 产品特性
- A DNA sequence encoding the mouse ACVR1 (NP_031420.2) precursor (Met 1-Glu 123) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measure by its ability to bind with human BMP2 in a functional ELISA.
- Top Product
- Discover our top product ACRV1 蛋白
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Activin Receptor Type I (ACRV1) (AA 145-509) (Active) protein (GST tag)
ACRV1 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active
Activin Receptor Type I (ACRV1) (AA 145-509) (Active) protein (His-GST)ACRV1 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Activin Receptor Type I (ACRV1) (AA 1-509) protein (GST tag)ACRV1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Activin Receptor Type I (ACRV1) (AA 21-120) protein (GST tag)ACRV1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Activin Receptor Type I (ACRV1) protein (Fc Tag)ACRV1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Activin Receptor Type I (ACRV1) (AA 147-509) protein (His tag)Crystallography grade ACRV1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Activin Receptor Type I (ACRV1) (AA 21-123) protein (His tag)Crystallography grade ACRV1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Activin Receptor Type I (ACRV1) (AA 147-509) protein (His tag)Crystallography grade ACRV1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Activin Receptor Type I (ACRV1) (AA 21-123) protein (His tag)Crystallography grade ACRV1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Activin Receptor Type I (ACRV1) (AA 21-509) protein (rho-1D4 tag)Crystallography grade ACRV1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))
- 别名
- ALK-2/ACVR1 (ACRV1 产品)
- 别名
- ACTRI Protein, ACVR1A Protein, ACVRLK2 Protein, ALK2 Protein, FOP Protein, SKR1 Protein, TSRI Protein, ActR-IA Protein, ActR-I Protein, ActRIA Protein, Acvr Protein, Acvrlk2 Protein, Alk-2 Protein, Alk8 Protein, D330013D15Rik Protein, Tsk7L Protein, actri Protein, acvr1 Protein, acvr1-a Protein, acvr1-b Protein, acvr1a Protein, acvrlk2 Protein, alk-2 Protein, alk2 Protein, alk8 Protein, fop Protein, sax Protein, skr1 Protein, tsri Protein, xALK-2 Protein, activin A receptor type 1 Protein, activin A receptor, type 1 Protein, activin A receptor type 1 S homeolog Protein, ACVR1 Protein, Acvr1 Protein, acvr1.S Protein
- 背景
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Background: ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).
Synonym: ActR-I,ActRIA,Acvr,Acvrlk2,Alk-2,ALK2,Alk8,D330013D15Rik,SKR1,Tsk7L
- 分子量
- 40 kDa
- NCBI登录号
- NP_031420
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