ACP1 Protein (GST tag)
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- 抗原 See all ACP1 蛋白
- ACP1 (Acid Phosphatase 1, Soluble (ACP1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This ACP1 protein is labelled with GST tag.
- 原理
- Recombinant Human ACP1/LMW-PTP Protein (GST Tag)(Active)
- 序列
- Met 1-His 158
- 产品特性
- A DNA sequence encoding human ACP1 (AAI06012.1) (Met 1-His 158) was fused with the GST tag at the N-terminus.
- 纯度
- > 88 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- Measured by its ability to cleave a substrate, pNitrophenyl phosphate (pNPP). The specific activity is >65,000 pmol/min/μg.
- Top Product
- Discover our top product ACP1 蛋白
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Acid Phosphatase 1, Soluble (ACP1) (AA 1-158) protein (GST tag)
ACP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA, PAA
Acid Phosphatase 1, Soluble (ACP1) (AA 1-158) (Active) protein (His tag)ACP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 150 mM NaCl, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- ACP1 (Acid Phosphatase 1, Soluble (ACP1))
- 别名
- ACP1/LMW-PTP (ACP1 产品)
- 别名
- HAAP Protein, 4632432E04Rik Protein, AI427468 Protein, Acp-1 Protein, LMW-PTP Protein, haap Protein, lmw-ptp Protein, ptp1a Protein, xlptp1 Protein, im:6910498 Protein, zgc:110844 Protein, Acp1 Protein, ACYPI006806 Protein, ACP Protein, ACPH Protein, APH Protein, Acph Protein, CG7899 Protein, Dmel\\CG7899 Protein, DDBDRAFT_0189318 Protein, DDBDRAFT_0266663 Protein, DDB_0189318 Protein, DDB_0266663 Protein, ACP1 Protein, XLPTP1 Protein, acp1 Protein, acp1a Protein, ptp1a-A Protein, LMW-PTPase Protein, acid phosphatase 1 Protein, acid phosphatase 1, soluble Protein, Acid phosphatase 1 Protein, acid phosphatase 1 L homeolog Protein, ACP1 Protein, Acp1 Protein, acp1 Protein, Acph-1 Protein, acp1.L Protein
- 背景
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Background: The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphorylate activated PDGF receptor, thus modulating PDGF-induced mitogenesis. In vitro, LMW-PTP was found to efficiently dephosphorylate activated FcgammaRIIA and LAT, but not Syk or phospholipase Cgamma2. The overexpression of LMW-PTP inhibited activation of Syk downstream of FcgammaRIIA and reduced intracellular Ca(2+) mobilization. It been demonstrated that LMW-PTP is responsible for FcgammaRIIA dephosphorylation, and is implicated in the down-regulation of cell activation mediated by this ITAM-bearing immunoreceptor. In addition, ACP1 is a highly polymorphic phosphatase that is especially abundant in the central nervous system and is known to be involved in several signal transduction pathways.
Synonym: HAAP,Low Molecular Weight Phosphotyrosine Protein Phosphatase, LMW-PTP, LMW-PTPase, Adipocyte Acid Phosphatase, Low Molecular Weight Cytosolic Acid Phosphatase, Red Cell Acid Phosphatase 1, ACP1
- 分子量
- 44.3 kDa
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